An Qingming, Zhou Huitong, Hu Jiang, Luo Yuzhu, Hickford Jon G H
Faculty of Wujiang, Tongren University, Tongren 554300, China.
Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Genes (Basel). 2017 Jun 12;8(6):160. doi: 10.3390/genes8060160.
Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene () haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplotypes were found in these lambs and they were composed of the four previously reported promoter fragment sequences (-) and three previously reported intron 2-exon 3 sequences (-). The frequencies of the haplotypes ranged from 0.07% to 45.91%. The presence of - was associated with a decreased pre-weaning growth rate ( = 0.037), and decreased leg lean-meat yield ( = 0.001), loin lean-meat yield ( = 0.018) and total lean-meat yield ( = 0.004). The presence of - was associated with increased carcass fat depth over the 12th rib (V-GR; = 0.001) and a decreased proportion of loin lean-meat yield ( = 0.045). The presence of - was associated with an increased proportion of leg lean-meat yield ( = 0.016) and proportion of shoulder lean-meat yield ( = 0.030). No associations were found with birth weight, tailing weight and weaning weight. These results suggest that ovine may have value as a genetic marker for NZ Romney sheep breeding.
脂联素在哺乳动物脂肪组织的能量稳态和代谢中发挥着重要作用。在本研究中，使用一般线性模型（GLMs）研究了脂联素基因（）单倍型与新西兰罗姆尼羔羊生长和胴体性状变异之间的关系。在这些羔羊中发现了8种单倍型，它们由先前报道的4个启动子片段序列（-）和3个先前报道的内含子2-外显子3序列（-）组成。单倍型频率范围为0.07%至45.91%。-的存在与断奶前生长速率降低（=0.037）、腿部瘦肉产量降低（=0.001）、腰部瘦肉产量降低（=0.018）和总瘦肉产量降低（=0.004）相关。-的存在与第12肋处胴体脂肪深度增加（V-GR；=0.001）和腰部瘦肉产量比例降低（=0.045）相关。-的存在与腿部瘦肉产量比例增加（=0.016）和肩部瘦肉产量比例增加（=0.030）相关。未发现与出生体重、去尾体重和断奶体重有相关性。这些结果表明，绵羊可能作为新西兰罗姆尼羊育种的遗传标记具有价值。
