First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Cytokine. 2013 Feb;61(2):565-71. doi: 10.1016/j.cyto.2012.10.030. Epub 2012 Nov 27.
The results of studies investigating the association between ADIPOQ gene polymorphisms and risk of cancer have been inconsistent and often contradictory. The present meta-analysis was conducted in order to overcome the limitations of any individual study and to provide a more precise overall effect estimate. Relevant studies were identified by searching PubMed and Embase for articles published through May 2012. The strength of the relationship between the ADIPOQ gene and risk of cancer was assessed using odds ratios (ORs). Either a fixed-effects or a random-effects model was used to calculate the overall risk estimates. Fifteen studies were included and five SNPs were considered. A significant association was found between SNP rs2241766 and risk of cancer in the recessive genetic model (OR: 0.768, 95% CI: [0.626,0.942], P=0.011); a significant relationship was also found between SNP rs1501299 and risk of cancer in both an allele contrast (OR: 0.141, 95%CI: [0.113,0.176], P<0.001) and the dominant genetic model (OR: 0.904, 95%CI: [0.830,0.985], P=0.021); no association was found with the rs266729, rs822395, or rs822396 SNPs. Adjusted ORs were also considered, but no statistically significant association was found in homozygote contrasts for any of the five SNPs after adjustment. Our results suggest that two polymorphisms, SNP rs2241766 and SNP rs1501299, of the ADIPOQ gene may be associated with reduced risk of cancer. However, the overall strength of association is mild to moderate, and additional well-designed studies are needed to confirm the present conclusion.
研究 ADIPOQ 基因多态性与癌症风险之间关联的结果一直不一致，且常常相互矛盾。本荟萃分析旨在克服任何单一研究的局限性，并提供更精确的总体效应估计。通过检索 PubMed 和 Embase 数据库，查找截至 2012 年 5 月发表的文章，确定了相关研究。使用比值比（ORs）评估 ADIPOQ 基因与癌症风险之间的关系强度。使用固定效应或随机效应模型计算总体风险估计值。纳入了 15 项研究，考虑了 5 个 SNP。在隐性遗传模型中，SNP rs2241766 与癌症风险之间存在显著关联（OR：0.768，95%CI：[0.626,0.942]，P=0.011）；在等位基因对比（OR：0.141，95%CI：[0.113,0.176]，P<0.001）和显性遗传模型（OR：0.904，95%CI：[0.830,0.985]，P=0.021）中，SNP rs1501299 与癌症风险之间也存在显著关联；而 rs266729、rs822395 和 rs822396 这 3 个 SNP 与癌症风险之间无关联。也考虑了校正后的 OR，但在对这 5 个 SNP 的任何一种同型对比进行校正后，均未发现有统计学意义的关联。我们的结果表明，ADIPOQ 基因的两个多态性 SNP rs2241766 和 SNP rs1501299 可能与癌症风险降低相关。然而，关联的总体强度为轻度至中度，需要更多设计良好的研究来证实目前的结论。
