一种基于工程化血红蛋白的超分子组装体，其表现出热刺激驱动的向新的独特超分子结构的转变。
A supramolecular assembly based on an engineered hemoprotein exhibiting a thermal stimulus-driven conversion to a new distinct supramolecular structure.
作者信息
Oohora Koji, Onuma Yoshitaka, Tanaka Yuta, Onoda Akira, Hayashi Takashi
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871, Japan.
出版信息
Chem Commun (Camb). 2017 Jun 22;53(51):6879-6882. doi: 10.1039/c7cc02678a.
PMID:28604909
Abstract
Supramolecular assembly of an engineered hemoprotein with an externally-attached heme moiety via an azobenzene or stilbene linker demonstrates drastic structural transitions between two distinct forms: the thermodynamically stable fiber-type assembly and the kinetically trapped metastable micelle-type assembly induced by transient thermal stimulus.
摘要
一种经过工程改造的血蛋白通过偶氮苯或芪连接体与外部连接的血红素部分进行超分子组装，展示了两种不同形式之间的剧烈结构转变：热力学稳定的纤维型组装和由瞬态热刺激诱导的动力学捕获的亚稳态胶束型组装。
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