胰腺癌微环境：一个真正的双面间谍。
The pancreatic cancer microenvironment: A true double agent.
作者信息
Melstrom Laleh G, Salazar Marcela D, Diamond Don J
机构信息
Department of Surgery and Experimental Therapeutics, City of Hope National Medical Center, Duarte, California.
Department of Experimental Therapeutics, City of Hope National Medical Center, Duarte, California.
出版信息
J Surg Oncol. 2017 Jul;116(1):7-15. doi: 10.1002/jso.24643. Epub 2017 Jun 12.
Abstract
The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.
摘要
胰腺癌中的肿瘤微环境是促肿瘤和抗肿瘤成分的复杂平衡。致密的促结缔组织增生由免疫细胞、细胞外基质、生长因子、细胞因子以及癌症相关成纤维细胞（CAF）或胰腺星状细胞（PSC）组成。存在众多靶点，包括透明质酸、血管生成、粘着斑激酶（FAK）、结缔组织生长因子（CTGF）、CD40、趋化因子（C-X-C基序）受体4（CXCR-4）、免疫疗法和维生素D。将对正在研发的临床治疗方法进行综述。
相似文献
1
The pancreatic cancer microenvironment: A true double agent.胰腺癌微环境：一个真正的双面间谍。
J Surg Oncol. 2017 Jul;116(1):7-15. doi: 10.1002/jso.24643. Epub 2017 Jun 12.
2
The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer.癌症相关成纤维细胞对胰腺癌主要特征的影响。
Theranostics. 2018 Oct 6;8(18):5072-5087. doi: 10.7150/thno.26546. eCollection 2018.
3
Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma.持续激活的胰腺星状细胞为胰腺导管腺癌的恶性行为创造了有利的微环境。
Int J Cancer. 2013 Mar 1;132(5):993-1003. doi: 10.1002/ijc.27715. Epub 2012 Oct 5.
4
Stellate Cells in the Tumor Microenvironment.肿瘤微环境中的星状细胞
Adv Exp Med Biol. 2020;1263:67-84. doi: 10.1007/978-3-030-44518-8_6.
5
The Pancreatic Cancer Microenvironment.胰腺癌微环境
Cancer J. 2017 Nov/Dec;23(6):321-325. doi: 10.1097/PPO.0000000000000288.
6
[The impact of desmoplasia and pancreatic stellate cells on pancreatic cancer].[促纤维增生及胰腺星状细胞对胰腺癌的影响]
Ugeskr Laeger. 2015 Aug 17;177(34).
7
Pancreatic cancer stroma: controversies and current insights.胰腺癌基质：争议与当前见解
Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):641-646. doi: 10.1080/00365521.2017.1293726. Epub 2017 Feb 24.
8
Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity.炎症与胰腺癌：聚焦代谢、细胞因子与免疫。
Int J Mol Sci. 2019 Feb 5;20(3):676. doi: 10.3390/ijms20030676.
9
Immunotherapy of pancreatic cancer.胰腺癌的免疫治疗。
Prog Mol Biol Transl Sci. 2019;164:189-216. doi: 10.1016/bs.pmbts.2019.03.006. Epub 2019 Mar 22.
10
Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells.瞬时受体电位通道1（TRPC1）在压力介导的小鼠胰腺星状细胞激活中的作用
Eur Biophys J. 2016 Oct;45(7):657-670. doi: 10.1007/s00249-016-1176-4. Epub 2016 Sep 26.
引用本文的文献
1
Unraveling tumor cell‑tumor microenvironment crosstalk through antibody array technologies (Review).通过抗体阵列技术解析肿瘤细胞与肿瘤微环境的相互作用（综述）
Int J Oncol. 2025 Oct;67(4). doi: 10.3892/ijo.2025.5787. Epub 2025 Aug 24.
2
Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts.通过阻断癌症相关成纤维细胞上的纤连蛋白结合整合素来靶向胰腺癌干细胞特性
Cancer Res Commun. 2025 Jan 1;5(1):195-208. doi: 10.1158/2767-9764.CRC-24-0491.
3
High-throughput glycosaminoglycan extraction and UHPLC-MS/MS quantification in human biofluids.人生物流体中高通量糖胺聚糖提取及超高效液相色谱-串联质谱定量分析
Nat Protoc. 2025 Apr;20(4):843-860. doi: 10.1038/s41596-024-01078-9. Epub 2024 Nov 14.
4
PET imaging with [Ga]-labeled TGFβ-targeting peptide in a mouse PANC-1 tumor model.在小鼠PANC - 1肿瘤模型中使用[镓]标记的靶向转化生长因子β（TGFβ）肽进行正电子发射断层扫描（PET）成像。
Front Oncol. 2023 Sep 15;13:1228281. doi: 10.3389/fonc.2023.1228281. eCollection 2023.
5
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis.胰腺褪黑素通过调节肿瘤相关中性粒细胞浸润和中性粒细胞胞外陷阱形成来增强胰腺腺癌的抗肿瘤免疫力。
Acta Pharm Sin B. 2023 Apr;13(4):1554-1567. doi: 10.1016/j.apsb.2023.01.020. Epub 2023 Feb 2.
6
The role of CXCL12 axis in pancreatic cancer: New biomarkers and potential targets.CXCL12轴在胰腺癌中的作用：新的生物标志物和潜在靶点。
Front Oncol. 2023 Mar 23;13:1154581. doi: 10.3389/fonc.2023.1154581. eCollection 2023.
7
Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.肥胖和糖尿病相关的胰腺癌发病机制：全面系统的综述。
Signal Transduct Target Ther. 2023 Mar 24;8(1):139. doi: 10.1038/s41392-023-01376-w.
8
Enhanced effect of X-rays in the presence of a static magnetic field within a 3D pancreatic cancer model.在三维胰腺癌模型中存在静磁场时 X 射线的增强效应。
Br J Radiol. 2023 Mar;96(1143):20220832. doi: 10.1259/bjr.20220832. Epub 2023 Jan 14.
9
Investigation of key signaling pathways and appropriate diagnostic biomarkers selection between non-invasive to invasive stages in pancreatic cancer: a computational observation.探讨胰腺癌从非侵袭性到侵袭性阶段的关键信号通路和合适的诊断生物标志物选择：一项计算观察。
J Med Life. 2022 Sep;15(9):1143-1157. doi: 10.25122/jml-2022-0067.
10
Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer.胰腺癌中癌症相关成纤维细胞和肿瘤免疫微环境的异质性
Cancers (Basel). 2022 Aug 18;14(16):3994. doi: 10.3390/cancers14163994.
本文引用的文献
1
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial.比较吉西他滨和卡培他滨辅助治疗与吉西他滨单药治疗可切除胰腺癌患者的效果（ESPAC-4）：一项多中心、开放标签、随机、3 期临床试验。
Lancet. 2017 Mar 11;389(10073):1011-1024. doi: 10.1016/S0140-6736(16)32409-6. Epub 2017 Jan 25.
2
Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer.纳米白蛋白结合型紫杉醇的巨胞饮作用驱动胰腺癌中的巨噬细胞活化。
Cancer Immunol Res. 2017 Mar;5(3):182-190. doi: 10.1158/2326-6066.CIR-16-0125. Epub 2017 Jan 20.
3
Pancreatic cancer: Stroma and its current and emerging targeted therapies.胰腺癌：基质及其当前和新兴的靶向治疗
Cancer Lett. 2017 Apr 10;391:38-49. doi: 10.1016/j.canlet.2016.12.035. Epub 2017 Jan 14.
4
Cancer Statistics, 2017.《2017 年癌症统计》
CA Cancer J Clin. 2017 Jan;67(1):7-30. doi: 10.3322/caac.21387. Epub 2017 Jan 5.
5
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.靶向粘着斑激酶可使胰腺癌对检查点免疫疗法产生反应。
Nat Med. 2016 Aug;22(8):851-60. doi: 10.1038/nm.4123. Epub 2016 Jul 4.
6
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.CXCR2抑制可显著抑制胰腺导管腺癌的转移并增强免疫治疗效果。
Cancer Cell. 2016 Jun 13;29(6):832-845. doi: 10.1016/j.ccell.2016.04.014. Epub 2016 Jun 2.
7
Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.将源自HapT1的同源肿瘤作为临床前模型进行表征和应用，以评估针对胰腺肿瘤纤维增生的药物治疗效果。
Oncotarget. 2016 Jul 5;7(27):41825-41842. doi: 10.18632/oncotarget.9729.
8
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.通过抗体靶向重编程肿瘤相关巨噬细胞可抑制癌症进展和转移。
Cell Rep. 2016 May 31;15(9):2000-11. doi: 10.1016/j.celrep.2016.04.084. Epub 2016 May 19.
9
Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression.胰腺癌微环境中中性粒细胞衍生的蛋白酶——肿瘤进展的活跃参与者
Int J Biol Sci. 2016 Jan 28;12(3):302-13. doi: 10.7150/ijbs.14996. eCollection 2016.
10
An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer.一种整合抗纤维化和化疗药物的MMP-2响应脂质体，用于增强胰腺癌的药物灌注和疗效。
ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3438-45. doi: 10.1021/acsami.5b11619. Epub 2016 Jan 26.
Zotero 插件