Hille Katja, Ruddat Inga, Schmid Annette, Hering Johanna, Hartmann Maria, von Münchhausen Christiane, Schneider Bettina, Messelhäusser Ute, Friese Anika, Mansfeld Rolf, Käsbohrer Annemarie, Hörmansdorfer Stefan, Roesler Uwe, Kreienbrock Lothar
Department of Biometry, Epidemiology and Information Processing, WHO-CC for Research and Training for Health at the Human-Animal-Environment Interface, University of Veterinary Medicine Hannover, Bünteweg 2, D-30559 Hannover, Germany.
Department of Biometry, Epidemiology and Information Processing, WHO-CC for Research and Training for Health at the Human-Animal-Environment Interface, University of Veterinary Medicine Hannover, Bünteweg 2, D-30559 Hannover, Germany.
Prev Vet Med. 2017 Jul 1;142:39-45. doi: 10.1016/j.prevetmed.2017.05.003. Epub 2017 May 3.
Resistance to third-generation cephalosporins and other beta-lactam antibiotics is of major concern for animal and human health. Knowledge of the prevalence of resistant bacteria in primary production is an important element to estimate transmission along the stages in the food production chain and the exposure of the human population. The primary objective of this study was to determine the prevalence of cefotaxime-resistant commensal E. coli in dairy and beef cattle production units throughout Germany. Secondarily, the association between management factors and the presence of cefotaxime resistance was investigated. In total, 60 beef cattle and 52 dairy cattle production units all over Germany were included. Cefotaxime-resistant E. coli were isolated from at least one sample in 70% (95% CI: 58-83%) of the farms keeping beef cattle and 85% (95% CI: 75-94%) of the farms keeping dairy cattle. The sample prevalence was 35% (161/455; 95% CI: 31-40%) and 48% (156/323; 95% CI: 43-54%), respectively. Most factors associated with resistance to cefotaxime indicate that less intensive production results in a lower number of positive samples. For beef cattle, antimicrobial treatment of the whole animal group was significantly associated with an increased proportion of samples containing cefotaxime resistant E. coli. In addition, our results indicate that better hygiene management could improve the resistance situation on cattle farms.
对第三代头孢菌素和其他β-内酰胺类抗生素的耐药性是动物和人类健康的主要关注点。了解初级生产中耐药细菌的流行情况是估计食品生产链各阶段传播情况以及人群暴露情况的重要因素。本研究的主要目的是确定德国各地奶牛和肉牛养殖场中对头孢噻肟耐药的共生大肠杆菌的流行情况。其次，研究了管理因素与头孢噻肟耐药性存在之间的关联。总共纳入了德国各地的60个肉牛养殖场和52个奶牛养殖场。在饲养肉牛的农场中，70%（95%置信区间：58 - 83%）的农场至少有一个样本分离出了对头孢噻肟耐药的大肠杆菌；在饲养奶牛的农场中，这一比例为85%（95%置信区间：75 - 94%）。样本流行率分别为35%（161/455；95%置信区间：31 - 40%）和48%（156/323；95%置信区间：43 - 54%）。大多数与头孢噻肟耐药性相关的因素表明，生产集约化程度较低会导致阳性样本数量减少。对于肉牛，对整个牛群进行抗菌治疗与含有头孢噻肟耐药大肠杆菌的样本比例增加显著相关。此外，我们的结果表明，更好的卫生管理可以改善养牛场的耐药情况。
