Lehrstuhl für Biomedizinische Physik, Physik-Department & Munich School of BioEngineering, Technische Universität München, 85748, Garching, Germany.
Computer Aided Medical Procedures, Technische Universität München, 85748, Garching, Germany.
Sci Rep. 2017 Jun 12;7(1):3307. doi: 10.1038/s41598-017-03307-6.
Dark-field imaging is a scattering-based X-ray imaging method that can be performed with laboratory X-ray tubes. The possibility to obtain information about unresolvable structures has already seen a lot of interest for both medical and material science applications. Unlike conventional X-ray attenuation, orientation dependent changes of the dark-field signal can be used to reveal microscopic structural orientation. To date, reconstruction of the three-dimensional dark-field signal requires dedicated, highly complex algorithms and specialized acquisition hardware. This severely hinders the possible application of orientation-dependent dark-field tomography. In this paper, we show that it is possible to perform this kind of dark-field tomography with common Talbot-Lau interferometer setups by reducing the reconstruction to several smaller independent problems. This allows for the reconstruction to be performed with commercially available software and our findings will therefore help pave the way for a straightforward implementation of orientation-dependent dark-field tomography.
暗场成像是一种基于散射的 X 射线成像方法，可以使用实验室 X 射线管进行。由于能够获取不可分辨结构的信息，这种方法已经在医学和材料科学领域引起了广泛的关注。与传统的 X 射线衰减不同，暗场信号的方向依赖性变化可用于揭示微观结构的方向。迄今为止，三维暗场信号的重建需要专用的、高度复杂的算法和专门的采集硬件，这严重阻碍了基于方向的暗场层析成像的应用。在本文中，我们证明了通过将重建问题简化为几个较小的独立问题，使用常见的泰伯-劳厄干涉仪设置进行这种暗场层析成像的可能性。这使得可以使用商业上可用的软件进行重建，因此我们的研究结果将有助于为基于方向的暗场层析成像的直接实现铺平道路。
