Institute of Materials Science & Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
J Agric Food Chem. 2017 Jul 5;65(26):5404-5412. doi: 10.1021/acs.jafc.7b01562. Epub 2017 Jun 23.
Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratios (Vitamin E/HPβCD; 1:2 and 1:1), which correspond to theoretical value of ∼13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ∼11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF. Because of the cyclodextrin inclusion complexation, only a minimal weight loss (only ∼2% w/w) was observed. While pure Vitamin E is insoluble in water, Vitamin E/HPβCD-IC NF web has displayed fast-dissolving behavior. Because of the greatly enhanced water-solubility of Vitamin E, Vitamin E/HPβCD-IC NF web has shown effective antioxidant activity. Additionally, Vitamin E/HPβCD-IC NF web has provided enhanced photostability for the sensitive Vitamin E by the inclusion complexation in which Vitamin E/HPβCD-IC NF still kept its antioxidant activity even after exposure to UV-light. Moreover, a 3 year-old Vitamin E/HPβCD-IC NF sample has shown very similar antioxidant efficiency when compared with freshly prepared Vitamin E/HPβCD-IC NF indicating that long-term stability was achieved for Vitamin E in the CD-IC fiber matrix. In brief, our results suggested that polymer-free electrospun Vitamin E/HPβCD-IC nanofibrous webs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antioxidant activity along with enhanced water-solubility, prolonged shelf life, and high photostability of Vitamin E.
在这里，我们展示了从羟丙基-β-环糊精（HPβCD）和维生素 E（维生素 E/HPβCD-IC NF）的包合物（IC）中电纺制得的无聚合物纳米纤维网。通过使用两种不同的摩尔比（维生素 E/HPβCD；1:2 和 1:1）制备 HPβCD 和维生素 E 之间的包合，这对应于理论值约为 13%（w/w）和 26%（w/w）负载量的纳米纤维（NF）基质中的维生素 E。电纺和储存后，在维生素 E/HPβCD-IC NF 中保留了非常高的维生素 E 负载量（相对于纤维基质高达约 11% w/w）。由于环糊精包合，仅观察到最小的重量损失（仅约 2% w/w）。虽然纯维生素 E 不溶于水，但维生素 E/HPβCD-IC NF 网具有快速溶解的行为。由于维生素 E 的水溶性大大增强，维生素 E/HPβCD-IC NF 网具有有效的抗氧化活性。此外，由于维生素 E/HPβCD-IC NF 网在包含复合物中，维生素 E/HPβCD-IC NF 网对敏感的维生素 E 提供了增强的光稳定性，即使在暴露于紫外线下，维生素 E/HPβCD-IC NF 仍保持其抗氧化活性。此外，与新制备的维生素 E/HPβCD-IC NF 相比，3 年的维生素 E/HPβCD-IC NF 样品显示出非常相似的抗氧化效率，这表明维生素 E 在 CD-IC 纤维基质中实现了长期稳定性。总之，我们的结果表明，无聚合物电纺制的维生素 E/HPβCD-IC 纳米纤维网由于其高效的抗氧化活性以及增强的水溶性、延长的保质期和高维生素 E 的光稳定性，可能在食品、制药和保健领域有潜在的应用。
