Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2024 Oct 11;14(1):23796. doi: 10.1038/s41598-024-74865-9.
Wound management is a critical aspect of healthcare, necessitating effective and innovative wound dressing materials. Many existing wound dressings lack effectiveness and exhibit limitations, including poor antimicrobial activity, toxicity, inadequate moisture regulation, and weak mechanical performance. The aim of this study is to develop a natural-based nanofibrous structure that possesses desirable characteristics for use as a wound dressing. The chemical analysis confirmed the successful creation of Zein (Ze) (25% w/v) /gelatin (Gel) (10% w/v) /chitosan (CS) (2% w/v) /Polyvinyl alcohol (PVA) (10% w/v) nanofibrous scaffolds loaded with vitamin E tocopheryl polyethylene glycol succinate (Vit E). The swelling percentages of nanofiber (NF), NF + Vit E, cross-linked nanofiber (CNF), and CNF + Vit E were 49%, 110%, 410%, and 676%, respectively; and the degradation rates of NF, NF + Vit E, CNF, and CNF + Vit E were 29.57 ± 5.06%, 33.78 ± 7.8%, 14.03 ± 7.52%, 43 ± 6.27%, respectively. The antibacterial properties demonstrated that CNF impregnated with antibiotics reduced Escherichia coli (E. coli) counts by approximately 27-28% and Staphylococcus aureus (S. aureus) counts by about 34-35% compared to negative control. In conclusion, cross-linked Ze/Gel/CS/PVA nanofibrous scaffolds loaded with Vit E have potential as suitable wound dressing materials because environmentally friendly materials contribute to sustainable wound care and controlled degradation ensures wound dressings breakdown harmlessly.
伤口管理是医疗保健的一个关键方面，需要有效的和创新的伤口敷料材料。许多现有的伤口敷料缺乏有效性，并表现出局限性，包括抗菌活性差、毒性、水分调节不足和机械性能弱。本研究旨在开发一种具有作为伤口敷料所需特性的天然纳米纤维结构。化学分析证实成功制备了 Zein（Ze）（25%w/v）/明胶（Gel）（10%w/v）/壳聚糖（CS）（2%w/v）/聚乙烯醇（PVA）（10%w/v）纳米纤维支架，负载生育酚聚乙二醇琥珀酸酯（Vit E）。纳米纤维（NF）、NF+Vit E、交联纳米纤维（CNF）和 CNF+Vit E 的溶胀百分比分别为 49%、110%、410%和 676%；NF、NF+Vit E、CNF 和 CNF+Vit E 的降解率分别为 29.57±5.06%、33.78±7.8%、14.03±7.52%和 43±6.27%。抗菌性能表明，与阴性对照相比，载有抗生素的 CNF 可将大肠杆菌（E. coli）数量减少约 27-28%，将金黄色葡萄球菌（S. aureus）数量减少约 34-35%。总之，载有 Vit E 的交联 Ze/Gel/CS/PVA 纳米纤维支架具有作为合适伤口敷料材料的潜力，因为环保材料有助于可持续伤口护理，控制降解可确保伤口敷料无害地分解。
