From the *Division of Cancer Epidemiology, and Genetics, National Cancer Institute, NIH, Bethesda, MD; †Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; ‡DDL Diagnostic Laboratory, Voorburg, the Netherlands, §Information Management Systems, Rockville, MD, ¶International Agency for Research on Cancer, Lyon, France; and ∥Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, Costa Rica.
Sex Transm Dis. 2017 Jul;44(7):442-449. doi: 10.1097/OLQ.0000000000000625.
Oral human papillomavirus (HPV) infection and related oropharyngeal cancer are uncommon in lower-income countries, particularly compared to HPV-associated cervical cancer. However, little is known about the natural history of oral HPV in less-developed settings and how it compares to the natural history of cervical HPV.
Three hundred fifty women aged 22 to 33 years from the Costa Rica Vaccine Trial provided exfoliated cells from the cervical and oral regions at 2 visits 2 years apart. Samples from both visits were tested for 25 characterized α HPV types by the SPF10 PCR-DNA enzyme immunoassay-LiPA25 version 1 system. Risk factors for oral HPV persistence were calculated utilizing generalized estimating equations with a logistic link.
Among the 82 women with characterized α oral HPV DNA detected at baseline, 14 persisted and were detected 2 years later (17.6%; 95% confidence interval [CI], 10.9-28.5%) and was similar to the persistence of α cervical HPV (40/223; 17.7%; 95% CI, 13.1-23.9%; P = 0.86). Acquisition of new α oral HPV type was low; incident infection (1.7%; 95% CI, 0.6-3.7%).
Oral HPV DNA is uncommon in young women in Latin America, and often appears to clear within a few years at similar rates to cervical HPV.
在低收入国家，口腔人乳头瘤病毒（HPV）感染和相关的口咽癌并不常见，与 HPV 相关的宫颈癌相比更是如此。然而，对于欠发达地区口腔 HPV 的自然史及其与宫颈 HPV 的自然史的比较，人们知之甚少。
来自哥斯达黎加疫苗试验的 350 名年龄在 22 至 33 岁的女性在 2 次相隔 2 年的访视中提供了宫颈和口腔区域的脱落细胞。使用 SPF10 PCR-DNA 酶免疫测定-LiPA25 版本 1 系统对来自两次访问的样本进行了 25 种特征化的 α HPV 型检测。利用广义估计方程和逻辑链接计算口腔 HPV 持续存在的危险因素。
在基线时检测到具有特征化的 α 口腔 HPV DNA 的 82 名女性中，有 14 名持续存在并在 2 年后再次检测到（17.6%；95%置信区间 [CI]，10.9-28.5%），与 α 宫颈 HPV 的持续存在相似（40/223；17.7%；95%CI，13.1-23.9%；P=0.86）。新的 α 口腔 HPV 型感染率较低；新发感染率为 1.7%（95%CI，0.6-3.7%）。
在拉丁美洲的年轻女性中，口腔 HPV DNA 并不常见，通常在几年内清除，与宫颈 HPV 的清除率相似。
