Key Laboratory of Chemical Biology (Ministry of Education), Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University , 44 West Wenhua Road, Jinan 250012, People's Republic of China.
The Second Hospital of Shandong University , 247 Bei-Yuan Street, Jinan 250033, People's Republic of China.
J Nat Prod. 2017 Jun 23;80(6):1791-1797. doi: 10.1021/acs.jnatprod.6b01196. Epub 2017 Jun 13.
Three new triketides, botrysphones A-C (1-3) and six new isopimarane-type diterpenoids, botrysphins A-F (4-9), together with the known triketides sphaeropsidone (10) and chlorosphaeropsidone (11) and diterpenoids sphaeropsidins A and B (12 and 13), were obtained from culture of the fungus Botrysphaeria laricina associated with the moss Rhodobryum umgiganteum. The structures of the new compounds were established on the basis of extensive spectroscopic techniques including HRMS and 1D and 2D NMR data. Compounds 7 and 12 showed significant quinone reductase inducing activity in Hepa 1c1c7 cells.
从与巨型石蕊相关的地钱中分离得到一株与 Botrysphaeria laricina 相关的真菌，从中得到了三个新的三酮类化合物（1-3）和六个新的松香烷型二萜类化合物（4-9），以及已知的三酮类化合物 sphaeropsidone（10）和 chlorosphaeropsidone（11）和二萜类化合物 sphaeropsidins A 和 B（12 和 13）。这些新化合物的结构是基于广泛的光谱技术，包括高分辨质谱和 1D 和 2D NMR 数据确定的。化合物 7 和 12 在 Hepa 1c1c7 细胞中表现出显著的醌还原酶诱导活性。
