Department of Internal Medicine II, HSK Hospital, Teaching Hospital of the University Medicine of Mainz, Ludwig-Erhard-Strasse 100, 65199 Wiesbaden, Germany.
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):421-434. doi: 10.1038/nrgastro.2017.46. Epub 2017 Jun 14.
Multimodality imaging is an essential aspect of endoscopic surveillance for the detection of neoplastic lesions, such as dysplasia or intramucosal cancer, because it improves the efficacy of endoscopic surveillance and therapeutic procedures in the gastrointestinal tract. This approach reveals mucosal abnormalities that cannot be detected by standard endoscopy. Currently, these imaging techniques are divided into those for primary detection and those for targeted imaging and characterization, the latter being used to visualize areas of interest in detail and permit histological evaluation. This Review outlines the use of virtual chromoendoscopy, narrow-band imaging, autofluorescence imaging, optical coherence tomography, confocal endomicroscopy and volumetric laser endomicroscopy as new imaging techniques for diagnostic investigation of the gastrointestinal tract. Insights into use of multimodal endoscopic imaging for early disease detection, in particular for pre-malignant lesions, in the oesophagus, stomach and colon are described.
多模态成像技术是内镜监测的一个重要方面，可用于检测肿瘤性病变，如异型增生或黏膜内癌，因为它可以提高胃肠道内镜监测和治疗的效果。这种方法可以发现标准内镜无法检测到的黏膜异常。目前，这些成像技术可分为用于初步检测和用于靶向成像及特征描述的技术，后者用于详细显示感兴趣的区域，并允许进行组织学评估。本综述概述了虚拟染色内镜、窄带成像、自发荧光成像、光相干断层扫描、共聚焦内镜和容积激光共聚焦内镜等新技术在胃肠道诊断研究中的应用。文中还介绍了多模态内镜成像在食管、胃和结肠等部位早期疾病检测，特别是癌前病变检测中的应用。
