胃肠道中的光学分子成像。
Optical molecular imaging in the gastrointestinal tract.
作者信息
Carns Jennifer, Keahey Pelham, Quang Timothy, Anandasabapathy Sharmila, Richards-Kortum Rebecca
机构信息
Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005, USA.
出版信息
Gastrointest Endosc Clin N Am. 2013 Jul;23(3):707-23. doi: 10.1016/j.giec.2013.03.010. Epub 2013 May 14.
Abstract
Recent developments in optical molecular imaging allow for real-time identification of morphologic and biochemical changes in tissue associated with gastrointestinal neoplasia. This review summarizes widefield and high-resolution imaging modalities in preclinical and clinical evaluation for the detection of colorectal cancer and esophageal cancer. Widefield techniques discussed include high-definition white light endoscopy, narrow band imaging, autofluoresence imaging, and chromoendoscopy; high-resolution techniques discussed include probe-based confocal laser endomicroscopy, high-resolution microendoscopy, and optical coherence tomography. New approaches to enhance image contrast using vital dyes and molecular-specific targeted contrast agents are evaluated.
摘要
光学分子成像的最新进展使得能够实时识别与胃肠道肿瘤相关的组织形态学和生化变化。本综述总结了在结直肠癌和食管癌检测的临床前和临床评估中的宽视野和高分辨率成像模式。所讨论的宽视野技术包括高清白光内镜检查、窄带成像、自发荧光成像和色素内镜检查；所讨论的高分辨率技术包括基于探头的共聚焦激光显微内镜检查、高分辨率显微内镜检查和光学相干断层扫描。评估了使用活性染料和分子特异性靶向造影剂增强图像对比度的新方法。
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