三阴性乳腺癌的生物学亚型
Biological Subtypes of Triple-Negative Breast Cancer.
作者信息
Hubalek Michael, Czech Theresa, Müller Hannes
机构信息
Department of Gynecology and Obstetrics, Brustzentrum Schwaz, Bezirkskrankenhaus Schwaz, Schwaz, Austria.
Dept. of Gynecology and Obstretrics, Brustgesundheitzentrum Tirol, Medical University Innsbruck, Innsbruck, Austria.
出版信息
Breast Care (Basel). 2017 Mar;12(1):8-14. doi: 10.1159/000455820. Epub 2017 Feb 20.
Abstract
Triple-negative breast cancers (TNBCs) are defined as tumors that are negative for estrogen, progesterone and HER-2 receptor. At a percentage of 10-20% TNBCs represent a minority in all breast cancers. However, because of the poor prognosis this particular subtype, triple negative disease accounts for a disproportionate number of metastatic cases and breast cancer deaths. Identification of its subtypes is essential for understanding the biological characteristics and clinical behavior of TNBC, as well as for developing personalized treatments. This review will focus on the great progress that has been made in the past few years on identifying new targets in TNBC subtypes and a variety of new treatment options that are on the verge of routine clinical application.
摘要
三阴性乳腺癌（TNBC）被定义为雌激素、孕激素和HER-2受体均呈阴性的肿瘤。TNBC在所有乳腺癌中占比10%-20%，属于少数类型。然而，由于这种特殊亚型的预后较差，三阴性疾病在转移性病例和乳腺癌死亡病例中所占比例过高。识别其亚型对于了解TNBC的生物学特征和临床行为以及开发个性化治疗方法至关重要。本综述将聚焦于过去几年在识别TNBC亚型新靶点以及即将应用于常规临床的各种新治疗方案方面所取得的重大进展。
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