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患有特定神经系统疾病儿童头发中的生物元素。

Bioelements in hair of children with selected neurological disorders.

作者信息

Józefczuk Jan, Kasprzycka Wiktoria, Czarnecki Rafał, Graczyk Alfreda, Józefczuk Paweł, Krzysztof Magda, Lampart Urszula, Mrozowska-Ząbek Ewa, Surdy Weronika, Kwiatkowska-Graczyk Róża

机构信息

Paediatric Ward with the Paediatric Cardiology Unit - Specialist Hospital of the Holy Spirit in Sandomierz, Sandomierz, Poland.

Department of Biochemistry and Optical Spectroscopy, Institute of Optoelectronics - Military University of Technology in Warsaw, Warsaw, Poland.

出版信息

Acta Biochim Pol. 2017;64(2):279-285. doi: 10.18388/abp.2016_1380. Epub 2017 Jun 14.

Abstract

We have analyzed concentrations of magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn) and iron (Fe) in hair of a group of 82 children with mental retardation, in which 9 patients suffered from epilepsy, 18 from the Down's syndrome and 55 from cerebral palsy. Girls comprised little over 50% of the patients. In the group of boys with epilepsy, we found Mg, Ca, Cu and Fe deficiency, and normal level of Zn. In the group of girls with epilepsy, apart from low Fe concentration, a high level of Ca, Mg, Zn, and Cu was noted. For girls with the Down's syndrome, a high or normal level of Ca, Mg, Zn and Cu was found, whereas the Fe concentration varied and presented itself in a non-characteristic way. Both groups of children with cerebral palsy, i.e. boys and girls, displayed low Fe concentration in their hair; low Cu level was found in older patients as well. In this group of patients, we also noted high concentrations of Ca, Mg and Zn in girls and normal in boys. A high concentration of Ca in girls with cerebral palsy requires separate analysis. The obtained results could be useful as guidance in the direction and determination of the amount of possible patient nutritional supplementation.

摘要

我们分析了一组82名智力发育迟缓儿童头发中镁(Mg)、钙(Ca)、铜(Cu)、锌(Zn)和铁(Fe)的浓度,其中9名患者患有癫痫,18名患有唐氏综合征,55名患有脑瘫。女孩占患者总数的略多于50%。在患有癫痫的男孩组中,我们发现镁、钙、铜和铁缺乏,而锌水平正常。在患有癫痫的女孩组中,除了铁浓度较低外,还发现钙、镁、锌和铜水平较高。对于患有唐氏综合征的女孩,发现钙、镁、锌和铜水平较高或正常,而铁浓度各不相同且无特征性表现。两组脑瘫儿童,即男孩和女孩,头发中铁浓度都较低;老年患者头发中铜水平也较低。在这组患者中,我们还注意到女孩头发中钙、镁和锌浓度较高,而男孩则正常。脑瘫女孩中钙浓度较高需要单独分析。所得结果可用作指导患者可能的营养补充方向和确定补充量的依据。

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