Michgehl U, Pavenstädt H, Vollenbröker B
Internal Medicine D, University Hospital of Muenster, Albert-Schweitzer-Campus 1, A14, D-48149, Muenster, Germany.
Pflugers Arch. 2017 Aug;469(7-8):917-926. doi: 10.1007/s00424-017-2004-0. Epub 2017 Jun 13.
Cell polarity has a crucial role in organizing cells into tissues and in mediating transport processes and cell-cell communication. Especially the cells of the nephron require apicobasal polarity to establish and maintain their barrier function. The Crumbs complex including the integral membrane protein Crumbs, as well as Pals1 and Patj, is essential for the establishment of apicobasal polarity. The interactions of the core proteins and the interplay with other processes have been characterized in various epithelial cell lines in detail. Notably, Crb2 and Crb3 are expressed within the kidney and play an important role in the proper function of podocytes and tubules, respectively. The interaction of polarity proteins and components of the Hippo pathway-an evolutionarily highly conserved kinase cascade regulating cell proliferation, organ size, and tissue regeneration-has been discovered recently. Here, we discuss potential molecular and physiological links between the Crumbs complex and the Hippo pathway in renal cells.
细胞极性在将细胞组织成组织以及介导运输过程和细胞间通讯中起着至关重要的作用。特别是肾单位的细胞需要顶-基极性来建立和维持其屏障功能。包括整合膜蛋白Crumb、Pals1和Patj在内的Crumb复合物对于顶-基极性的建立至关重要。核心蛋白的相互作用以及与其他过程的相互作用已在各种上皮细胞系中得到详细表征。值得注意的是，Crb2和Crb3在肾脏中表达，分别在足细胞和肾小管的正常功能中发挥重要作用。极性蛋白与Hippo信号通路（一种进化上高度保守的激酶级联反应，调节细胞增殖、器官大小和组织再生）的成分之间的相互作用最近被发现。在这里，我们讨论了肾细胞中Crumb复合物与Hippo信号通路之间潜在的分子和生理联系。
