Cimaz Rolando, Fanti Eleonora, Mauro Angela, Voller Fabio, Rusconi Franca
Rheumatology Unit, Anna Meyer Children's Hospital, Viale Pieraccini 24, 50139, Florence, Italy.
Neurofarba Department, University of Florence, Florence, Italy.
Eur J Pediatr. 2017 Aug;176(8):1061-1065. doi: 10.1007/s00431-017-2947-3. Epub 2017 Jun 14.
Kawasaki disease is a systemic vasculitis with an acute and self-limited course. The incidence of the disease differs widely among ethnic groups and is higher in the Asian populations. In Italy, no recent data are available. We studied the epidemiology of Kawasaki disease in the years 2008-2013 in children 0-14 years old in Italy using hospital ICD-9 discharge codes with a thorough data cleaning for duplicates in order to select the first hospital admission for the disease. The disease peaked in the first 2 years of life, with 85.5% of cases under 5 years. Male/female ratio was 1.4:1. The incidence rate was 5.7 per 100,000 children 0-14 years old and 14.7 for children younger than 5 years. The incidence rose slightly during the study period and had a seasonal distribution, with higher incidence in spring. A coronary artery aneurysm was recorded in 2.2% of the patients younger than 5 years of age.
This is the first epidemiologic study on Kawasaki disease incidence in the country of Italy. Figures are in line but slightly higher than those reported for other European countries. What is known: • Kawasaki disease is more common in Asian populations. • European incidence data are scarce. What is new: • Epidemiological data in Italy show similar incidence, albeit slightly higher, than in other European countries. • Incidence data slightly rose in the recent past.
川崎病是一种具有急性自限病程的系统性血管炎。该病的发病率在不同种族间差异很大，在亚洲人群中更高。在意大利，目前尚无最新数据。我们使用国际疾病分类第九版（ICD - 9）医院出院编码，对意大利0至14岁儿童在2008 - 2013年期间的川崎病流行病学进行了研究，并对重复数据进行了全面清理，以选择该疾病的首次住院记录。该病在生命的头两年达到高峰，85.5%的病例年龄在5岁以下。男女比例为1.4:1。发病率为每10万名0至14岁儿童中有5.7例，5岁以下儿童为14.7例。在研究期间发病率略有上升，且有季节性分布，春季发病率较高。5岁以下患者中有2.2%记录有冠状动脉瘤。
这是意大利国内关于川崎病发病率的首次流行病学研究。数据与其他欧洲国家报告的数据相符，但略高。已知信息：• 川崎病在亚洲人群中更常见。• 欧洲的发病率数据稀缺。新发现：• 意大利的流行病学数据显示发病率与其他欧洲国家相似，尽管略高。• 近期发病率数据略有上升。
