O'Dorisio M S, Wood C L, O'Dorisio T M
J Immunol. 1985 Aug;135(2 Suppl):792s-796s.
Evidence is rapidly accumulating to support the existence of a neuroimmune axis. However, the precise role of individual neurotransmitters in regulating immune function remains to be elucidated. In this review we focus on the role of vasoactive intestinal peptide (VIP) in modulation of lymphocyte function. We examine its status as a neurotransmitter, including evidence for neuronal and possible extraneuronal sites of synthesis. Further, we present data to demonstrate the presence of VIP receptors in human lymphocytes and, using the Molt 4b lymphoblastic cell line as a model, show VIP-mediated activation of adenylate cyclase leading to cAMP-dependent protein kinase-mediated phosphorylation of a specific Molt protein. Finally, we discuss the functional significance of VIP receptors on lymphocytes and present a model of neuropeptide-induced inflammation with possible therapeutic applications of this exciting new field of neuroimmunology.
越来越多的证据支持神经免疫轴的存在。然而，单个神经递质在调节免疫功能中的确切作用仍有待阐明。在这篇综述中，我们聚焦于血管活性肠肽（VIP）在调节淋巴细胞功能中的作用。我们研究了它作为神经递质的状态，包括神经元合成部位以及可能的神经元外合成部位的证据。此外，我们展示数据证明人淋巴细胞中存在VIP受体，并以Molt 4b淋巴母细胞系为模型，表明VIP介导的腺苷酸环化酶激活导致环磷酸腺苷（cAMP）依赖性蛋白激酶介导的特定Molt蛋白磷酸化。最后，我们讨论淋巴细胞上VIP受体的功能意义，并提出一个神经肽诱导炎症的模型以及这一令人兴奋的神经免疫学新领域可能的治疗应用。
