JAMA. 1985 Jul 19;254(3):400-2.
This report examines the safety issues related to the nutritive sweetener aspartame, including possible toxic effects of aspartame's component amino acids, aspartic acid and phenylalanine, and its major decomposition products, methanol and diketopiperazine, and the potential synergistic effect of aspartame and dietary carbohydrate on brain neurochemicals. Available evidence suggests that consumption of aspartame by normal humans is safe and is not associated with serious adverse health effects. Individuals who need to control their phenylalanine intake should handle aspartame like any other source of phenylalanine.
本报告探讨了与营养甜味剂阿斯巴甜相关的安全问题，包括阿斯巴甜的组成氨基酸天冬氨酸和苯丙氨酸及其主要分解产物甲醇和二酮哌嗪可能产生的毒性作用，以及阿斯巴甜与膳食碳水化合物对脑神经化学物质的潜在协同作用。现有证据表明，正常人食用阿斯巴甜是安全的，且不会产生严重的健康不良影响。需要控制苯丙氨酸摄入量的个体应像对待任何其他苯丙氨酸来源一样处理阿斯巴甜。
