血根碱生物碱与羧基柱[6]芳烃的高效络合作用：pK 位移、溶解度增加及抗菌活性增强
Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: pK shift, increased solubility and enhanced antibacterial activity.
作者信息
Ping Guchuan, Wang Yiliang, Shen Lingyun, Wang Yuting, Hu Xiaoshi, Chen Junyi, Hu Bingwen, Cui Lei, Meng Qingbin, Li Chunju
机构信息
Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai 200444, P. R. China.
出版信息
Chem Commun (Camb). 2017 Jun 29;53(53):7381-7384. doi: 10.1039/c7cc02799k.
Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a K value of (2.4 ± 0.3) × 10 M in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pK, and enhance the antibacterial activity of SA.
本文描述了水溶性羧基柱[6]芳烃（CP6A）对生理活性物质血根碱（SA）的包封。CP6A的有效络合作用在pH 7.4时的K值为(2.4 ± 0.3) × 10 M，使SA的水溶性提高了4.3倍，pK发生了2.02的变化，并增强了SA的抗菌活性。
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