Ping Guchuan, Wang Yiliang, Shen Lingyun, Wang Yuting, Hu Xiaoshi, Chen Junyi, Hu Bingwen, Cui Lei, Meng Qingbin, Li Chunju
Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai 200444, P. R. China.
Chem Commun (Camb). 2017 Jun 29;53(53):7381-7384. doi: 10.1039/c7cc02799k.
Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a K value of (2.4 ± 0.3) × 10 M in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pK, and enhance the antibacterial activity of SA.
本文描述了水溶性羧基柱[6]芳烃（CP6A）对生理活性物质血根碱（SA）的包封。CP6A的有效络合作用在pH 7.4时的K值为(2.4 ± 0.3) × 10 M，使SA的水溶性提高了4.3倍，pK发生了2.02的变化，并增强了SA的抗菌活性。
