检测到由侵染豆科植物的真菌 Diaporthe toxica 产生的 Phomopsin A 的有毒甲基衍生物。
Detection of a Toxic Methylated Derivative of Phomopsin A Produced by the Legume-Infesting Fungus Diaporthe toxica.
机构信息
Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg , Grindelallee 117, 20146 Hamburg, Germany.
NMR Facility, Department of Chemistry, University of Hamburg , Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
出版信息
J Nat Prod. 2017 Jun 23;80(6):1930-1934. doi: 10.1021/acs.jnatprod.6b00662. Epub 2017 Jun 14.
Phomopsin A (PHO-A), produced by the fungus Diaporthe toxica, is a mycotoxin known to be responsible for fatal liver disease of lupin-fed sheep. The full spectrum of the toxic secondary metabolites produced by D. toxica is still unknown. PHO-A and the naturally occurring derivatives B-E have been subject to several studies to reveal their structures as well as chemical and toxicological properties. In this work, a methylated derivative (1) of PHO-A isolated from lupin seeds inoculated with D. toxica is described. It was characterized by high-resolution mass and NMR data and shown to be the N-methylated derivative of PHO-A. 1 is cytotoxic against HepG2 cells.
蓬毒素 A（PHO-A）是由真菌 Diaporthe toxica 产生的一种霉菌毒素，已知会导致食用羽扇豆的绵羊致命性肝病。D. toxica 产生的全部毒性次生代谢产物仍不清楚。PHO-A 和天然存在的衍生物 B-E 已经进行了多项研究，以揭示它们的结构以及化学和毒理学特性。在这项工作中，描述了从接种 D. toxica 的羽扇豆种子中分离出的 PHO-A 的甲基化衍生物（1）。它的结构特征是通过高分辨率质谱和 NMR 数据确定的，并表明是 PHO-A 的 N-甲基化衍生物。1 对 HepG2 细胞具有细胞毒性。
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