Wei Wei, Khan Babar, Dai Qun, Lin Jie, Kang Liqin, Rajput Nasir Ahmed, Yan Wei, Liu Guiyou
School of Life Sciences and Chemical Engineering, Jiangsu Second Normal University, Nanjing 211200, China.
College of Plant Protection, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing 210095, China.
J Fungi (Basel). 2023 Apr 7;9(4):453. doi: 10.3390/jof9040453.
species produce versatile secondary metabolites (SMs), including terpenoids, fatty acids, polyketides, steroids, and alkaloids. These structurally diverse SMs exhibit a wide range of biological activities, including cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, and phytotoxic activities, which could be exploited in the medical, agricultural, and other modern industries. This review comprehensively covers the production and biological potencies of isolated natural products from the genus associated with terrestrial and marine origins. A total of 275 SMs have been summarized from terrestrial (153; 55%) and marine (110; 41%) origins during the last twelve years, and 12 (4%) compounds are common to both environments. All secondary metabolites are categorized predominantly on the basis of their bioactivities (cytotoxic, antibacterial, antifungal, and miscellaneous activity). Overall, 134 bioactive compounds were isolated from terrestrial (92; 55%) and marine (42; 34%) origins, but about half the compounds did not report any kind of activity. The antiSMASH results suggested that strains are capable of encoding a wide range of SMs and have tremendous biosynthetic potential for new SMs. This study will be useful for future research on drug discovery from terrestrial and marine natural products.
物种产生多种次生代谢产物（SMs），包括萜类化合物、脂肪酸、聚酮化合物、类固醇和生物碱。这些结构多样的次生代谢产物具有广泛的生物活性，包括细胞毒性、抗真菌、抗菌、抗病毒、抗氧化、抗炎和植物毒性活性，可应用于医学、农业和其他现代产业。本综述全面涵盖了与陆地和海洋来源相关的该属中分离出的天然产物的生产和生物活性。在过去十二年中，共总结了来自陆地（153种；55%）和海洋（110种；41%）来源的275种次生代谢产物，其中12种（4%）化合物在两种环境中都有。所有次生代谢产物主要根据其生物活性（细胞毒性、抗菌、抗真菌和其他活性）进行分类。总体而言，从陆地（92种；55%）和海洋（42种；34%）来源分离出134种生物活性化合物，但约一半的化合物未报告任何类型的活性。antiSMASH结果表明，菌株能够编码多种次生代谢产物，并且具有产生新次生代谢产物的巨大生物合成潜力。这项研究将有助于未来从陆地和海洋天然产物中发现药物的研究。
