ORAI 钙通道。
ORAI Calcium Channels.
机构信息
The Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and
The National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
出版信息
Physiology (Bethesda). 2017 Jul;32(4):332-342. doi: 10.1152/physiol.00011.2017.
Abstract
In this review article, we discuss the different gene products and translational variants of ORAI proteins and their contribution to the makeup of different native calcium-conducting channels with distinct compositions and modes of activation. We also review the different modes of regulation of these distinct calcium channels and their impact on downstream cellular signaling controlling important physiological functions.
摘要
在这篇综述文章中，我们讨论了 ORAI 蛋白的不同基因产物和翻译后变体，以及它们对不同组成和激活方式的天然钙通道的形成的贡献。我们还回顾了这些不同钙通道的不同调节方式及其对下游细胞信号转导的影响，这些信号转导控制着重要的生理功能。
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本文引用的文献
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JCI Insight. 2017 Mar 23;2(6):e91166. doi: 10.1172/jci.insight.91166.
2
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Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714.
3
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Cell Metab. 2017 Mar 7;25(3):698-712. doi: 10.1016/j.cmet.2016.12.021. Epub 2017 Jan 26.
4
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Cell Calcium. 2017 May;63:33-39. doi: 10.1016/j.ceca.2016.12.009. Epub 2016 Dec 30.
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