Androulakis X Michelle, Krebs Kaitlin, Peterlin B Lee, Zhang Tianming, Maleki Nasim, Sen Souvik, Rorden Chris, Herath Priyantha
From the Departments of Neurology (X.M.A., K.K., S.S., P.H.), Statistics (T.Z.), and Psychology (C.R.), University of South Carolina, Columbia; Department of Neurology (B.L.P.), Johns Hopkins University, Baltimore, MD; and Department of Psychiatry (N.M.), Massachusetts General Hospital, Boston.
Neurology. 2017 Jul 11;89(2):163-169. doi: 10.1212/WNL.0000000000004089. Epub 2017 Jun 14.
To evaluate the intrinsic resting functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) network in women with chronic migraine (CM), and whether clinical features are associated with such abnormalities.
We analyzed resting-state connectivity in 29 women with CM as compared to age- and sex-matched controls. Relationships between clinical characteristics and changes in targeted networks connectivity were evaluated using a multivariate linear regression model.
All 3 major intrinsic brain networks were less coherent in CM (DMN: = 0.030, SN: = 0.007, CEN: = 0.002) as compared to controls. When stratified based on medication overuse headache (MOH) status, CM without MOH (DMN: = 0.029, SN: = 0.023, CEN: = 0.003) and CM with MOH (DMN: = 0.016, SN: = 0.016, CEN: = 0.015) were also less coherent as compared to controls. There was no difference in CM with MOH as compared to CM without MOH (DMN: = 0.382, SN: = 0.408, CEN: = 0.419). The frequency of moderate and severe headache days was associated with decreased connectivity in SN ( = 0.003) and CEN ( = 0.015), while cutaneous allodynia was associated with increased connectivity in SN ( = 0.011).
Our results demonstrated decreased overall resting-state functional connectivity of the 3 major intrinsic brain networks in women with CM, and these patterns were associated with frequency of moderate to severe headache and cutaneous allodynia.
评估慢性偏头痛（CM）女性患者默认模式网络（DMN）、突显网络（SN）和中央执行网络（CEN）的内在静息功能连接性，以及临床特征是否与这些异常相关。
我们分析了29例CM女性患者的静息态连接性，并与年龄和性别匹配的对照组进行比较。使用多元线性回归模型评估临床特征与目标网络连接性变化之间的关系。
与对照组相比，CM患者的所有3个主要内在脑网络的连贯性均较低（DMN： = 0.030，SN： = 0.007，CEN： = 0.002）。根据药物过度使用性头痛（MOH）状态分层时，无MOH的CM患者（DMN： = 0.029，SN： = 0.023，CEN： = 0.003）和有MOH的CM患者（DMN： = 0.016，SN： = 0.016，CEN： = 0.015）与对照组相比连贯性也较低。有MOH的CM患者与无MOH的CM患者之间无差异（DMN： = 0.382，SN： = 0.408，CEN： = 0.419）。中度和重度头痛天数的频率与SN（ = 0.003）和CEN（ = 0.015）连接性降低相关，而皮肤异常性疼痛与SN连接性增加相关（ = 0.011）。
我们的结果表明，CM女性患者中3个主要内在脑网络的整体静息态功能连接性降低，这些模式与中度至重度头痛频率和皮肤异常性疼痛相关。
