El-Agamy Amira, Oteaf Fayrouz, Berika Mohamed
Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Clin Ophthalmol. 2017 Jun 1;11:1045-1050. doi: 10.2147/OPTH.S131612. eCollection 2017.
This study was conducted to determine normative profile of anterior lamina cribrosa surface depth (ALCSD) in healthy Saudi females using Topcon Three-Dimensional (3D) Optical Coherence Tomography (OCT) 2000 - Spectral Domain (SD-OCT). In addition, the correlation between ALCSD and other clinical factors such as age, refractive error, intraocular pressure (IOP), central corneal thickness, anterior chamber depth, axial length, retinal nerve fiber layer thickness, and disk area was also assessed.
This study was a prospective, nonrandomized, cross-sectional, observational, and quantitative study.
This study included 191 eyes of 191 healthy Saudi females from the College of Applied Medical Sciences of King Saud University. Stereoscopic disk photographs were reconstructed using Topcon 3D OCT-2000 for all subjects. ALCSD was measured at three planes (superior, middle, and inferior) and defined as the distance from Bruch's membrane opening level (reference line) to anterior lamina cribrosa surface. Average of ALCSD at all planes was defined as mean ALCSD of the eye. Correlation between ALCSD and all the clinical factors was performed by linear regression analysis. Paired -test was performed in order to compare ALCSD at all planes.
In this study, the average ALCSD was 371.88±114.62 μm (range, 155-647.6 μm). Paired -test showed a significant difference between superior and middle planes (=0.004) and middle and inferior planes (=0.013). Using the same test, no significant difference between superior and inferior planes (=0.820) was observed. Generally, the largest ALCSD was in the middle plane. In addition, linear regression analysis showed no significant correlation between ALCSD and associated clinical factors.
This work is the first to provide the normative profile of ALCSD in Saudi females using Topcon 3D OCT-2000. Further studies are recommended for males, different ethnic populations, high myopic eyes, and different age groups using advanced imaging techniques such as enhanced depth imaging OCT.
本研究旨在利用拓普康三维（3D）光学相干断层扫描（OCT）2000 - 光谱域（SD - OCT）确定健康沙特女性的筛板前表面深度（ALCSD）的正常特征。此外，还评估了ALCSD与其他临床因素之间的相关性，这些因素包括年龄、屈光不正、眼压（IOP）、中央角膜厚度、前房深度、眼轴长度、视网膜神经纤维层厚度和视盘面积。
本研究是一项前瞻性、非随机、横断面、观察性和定量研究。
本研究纳入了沙特国王大学应用医学科学学院191名健康沙特女性的191只眼睛。对所有受试者使用拓普康3D OCT - 2000重建立体视盘照片。在三个平面（上方、中间和下方）测量ALCSD，并将其定义为从布鲁赫膜开口水平（参考线）到筛板前表面的距离。所有平面ALCSD的平均值定义为该眼的平均ALCSD。通过线性回归分析进行ALCSD与所有临床因素之间的相关性分析。进行配对t检验以比较所有平面的ALCSD。
在本研究中，平均ALCSD为371.88±114.62μm（范围，155 - 647.6μm）。配对t检验显示上方和中间平面之间存在显著差异（P = 0.004），中间和下方平面之间也存在显著差异（P = 0.013）。使用相同的检验，未观察到上方和下方平面之间存在显著差异（P = 0.820）。一般来说，最大的ALCSD在中间平面。此外，线性回归分析显示ALCSD与相关临床因素之间无显著相关性。
本研究首次使用拓普康3D OCT - 2000提供了沙特女性ALCSD的正常特征。建议使用增强深度成像OCT等先进成像技术对男性、不同种族人群、高度近视眼睛和不同年龄组进行进一步研究。
