Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon.
Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1531-9. doi: 10.1167/iovs.13-13382.
To assess the effect of age on spectral-domain optical coherence tomography (SDOCT)-detected lamina cribrosa depth while controlling for visual field (VF) status and retinal nerve fiber layer thickness (RNFLT) in 221 high-risk ocular hypertension and glaucoma patients enrolled in the Portland Progression Project.
In this cross-sectional study, each participant underwent 870-nm SDOCT to obtain high-resolution radial B-scans centered on the optic nerve head (ONH) and a standardized ophthalmologic examination, including automated perimetry, on the same day. For each ONH, an anterior lamina cribrosa surface depth (ALCSD) parameter was generated as the average perpendicular distance from each anterior lamina cribrosa surface point relative to Bruch's membrane opening (BMO) reference plane within all 24 delineated B-scans. The relative effects of age, age-corrected VF status (mean deviation [MD]), and RNFLT on ALCSD were analyzed.
The mean age ± SD of participants was 64 ± 11 years (range, 33-90 years). The relationship between ALCSD and MD was age-dependent. ALCSD = 407.68 - 67.13 × MD - 0.08 × Age + 0.89 × MD × Age (MD, P = 0.001; MD × Age, P = 0.004). The relationship between ALCSD and RNFLT may also be age-dependent but did not achieve significance (interaction term, P = 0.067). ALCSD increased with worse VF status in younger eyes but not in older eyes. In older eyes, the anterior lamina was shallower than in younger eyes for the same VF status and RNFLT.
These data are consistent with the concept that structure/structure and structure/function relationships change with age.
在控制视野（VF）状态和视网膜神经纤维层厚度（RNFLT）的情况下，评估 221 例高危眼压和青光眼患者的光谱域光学相干断层扫描（SDOCT）检测到的筛板深度随年龄的变化。
在这项横断面研究中，每位参与者都接受了 870nm 的 SDOCT 检查，以获得以视神经头（ONH）为中心的高分辨率径向 B 扫描，并在同一天进行了标准化的眼科检查，包括自动视野检查。对于每个 ONH，生成一个前筛板深度（ALCSD）参数，作为相对于 Bruch 膜开口（BMO）参考平面的每个前筛板表面点的平均垂直距离，所有 24 个描绘的 B 扫描中都有此参数。分析年龄、年龄校正后的 VF 状态（平均偏差[MD]）和 RNFLT 对 ALCSD 的相对影响。
参与者的平均年龄±标准差为 64±11 岁（范围，33-90 岁）。ALCSD 与 MD 的关系随年龄而变化。ALCSD=407.68-67.13×MD-0.08×年龄+0.89×MD×年龄（MD，P=0.001；MD×年龄，P=0.004）。ALCSD 与 RNFLT 的关系也可能随年龄而变化，但未达到显著性（交互项，P=0.067）。在年轻的眼中，ALCSD 随着 VF 状态的恶化而增加，但在年龄较大的眼中则不然。在年龄较大的眼中，对于相同的 VF 状态和 RNFLT，前筛板比年轻的眼睛浅。
这些数据与结构/结构和结构/功能关系随年龄变化的概念一致。
