Roy-Byrne P P, Joffe R T, Uhde T W, Post R M
Arch Gen Psychiatry. 1984 Dec;41(12):1150-3. doi: 10.1001/archpsyc.1984.01790230036005.
Thyroid function was examined in 50 affectively ill patients before and four weeks after carbamazepine treatment. Carbamazepine significantly and substantially decreased peripheral thyroid hormone levels while increases in thyrotropin levels, although significant, were of much smaller magnitude. Furthermore, the decreases in levels of thyroxine (T4) and free T4 were significantly greater in carbamazepine responders than in nonresponders. These findings are discussed in light of current theories of the role of the thyroid axis in affective illness.
对50名情感障碍患者在卡马西平治疗前及治疗四周后进行了甲状腺功能检查。卡马西平显著且大幅降低了外周甲状腺激素水平，而促甲状腺激素水平虽有显著升高，但其幅度要小得多。此外，卡马西平治疗有反应者的甲状腺素（T4）和游离T4水平下降幅度显著大于无反应者。根据目前关于甲状腺轴在情感障碍中作用的理论对这些发现进行了讨论。
