• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect.在缺乏精氨酸琥珀酸合成酶1（ASS1）的癌症中进行治疗性精氨酸饥饿可抑制瓦伯格效应。
Mol Cell Oncol. 2017 Mar 1;4(3):e1295131. doi: 10.1080/23723556.2017.1295131. eCollection 2017.
2
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.精氨酸剥夺抑制ASS1缺陷型癌症中的瓦伯格效应并上调谷氨酰胺回补和丝氨酸生物合成。
Cell Rep. 2017 Jan 24;18(4):991-1004. doi: 10.1016/j.celrep.2016.12.077.
3
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.黑色素瘤细胞中精氨酸脱亚氨酶的抗性与代谢重编程、葡萄糖依赖性和谷氨酰胺成瘾有关。
Mol Cancer Ther. 2013 Nov;12(11):2581-90. doi: 10.1158/1535-7163.MCT-13-0302. Epub 2013 Aug 26.
4
Amino Acid Uptake Measured by [F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas.氨基酸摄取的测定[F]AFETP 在 ASS1 缺陷肉瘤的精氨酸饥饿反应中增加。
Theranostics. 2018 Mar 7;8(8):2107-2116. doi: 10.7150/thno.22083. eCollection 2018.
5
Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.精氨酸琥珀酸合成酶1（ASS1）是靶向精氨酸和谷氨酰胺饥饿疗法化疗敏感性的常见代谢标志物。
Cancer Lett. 2017 Mar 1;388:54-63. doi: 10.1016/j.canlet.2016.11.028. Epub 2016 Nov 30.
6
A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma.细胞因子调控的巨噬细胞在 ASS1 缺陷性间皮瘤中介导对 ADI-PEG20（聚乙二醇化天冬酰胺酶）耐药中的作用。
Pharmacol Rep. 2023 Jun;75(3):570-584. doi: 10.1007/s43440-023-00480-6. Epub 2023 Apr 3.
7
Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.顺铂通过 DEC1、HIF-1α 和 c-Myc 转录网络对精氨酸饥饿疗法诱导的合成致死性进行调控，该调控通过 ASS1 的转录抑制实现，且与 ASS1 启动子 DNA 甲基化无关。
Oncotarget. 2016 Dec 13;7(50):82658-82670. doi: 10.18632/oncotarget.12308.
8
Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.精氨酸琥珀酸合成酶 1 启动子甲基化使淋巴瘤对精氨酸脱氨酶治疗、自噬和 caspase 依赖性细胞凋亡敏感。
Cell Death Dis. 2012 Jul 5;3(7):e342. doi: 10.1038/cddis.2012.83.
9
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.发现和靶向肉瘤对 ADI-PEG20 介导的微环境抵抗的非典型机制。
Clin Cancer Res. 2023 Aug 15;29(16):3189-3202. doi: 10.1158/1078-0432.CCR-22-2642.
10
Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.多胺合成途径的抑制与精氨琥珀酸合酶1的缺失具有合成致死性。
Cell Rep. 2016 Aug 9;16(6):1604-1613. doi: 10.1016/j.celrep.2016.06.097. Epub 2016 Jul 21.

引用本文的文献

1
PEGylated Recombinant Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts.聚乙二醇化重组蓖麻毒素耗竭精氨酸和赖氨酸并抑制肿瘤异种移植物的生长。
ACS Biomater Sci Eng. 2024 Jun 10;10(6):3825-3832. doi: 10.1021/acsbiomaterials.4c00473. Epub 2024 May 9.
2
Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.放射肿瘤学中的代谢重编程以提高治疗比
Front Oncol. 2021 May 10;11:653621. doi: 10.3389/fonc.2021.653621. eCollection 2021.
3
Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming.精氨酸饥饿的系统水平分析揭示了 MYC 和 ERK 的适应性代谢重编程。
Cell Death Dis. 2020 Aug 20;11(8):662. doi: 10.1038/s41419-020-02899-8.
4
Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.利用聚乙二醇化精氨酸脱亚氨酶（ADI-PEG20）通过代谢失调使胰腺癌细胞对放射治疗敏感。
Mol Cancer Ther. 2019 Dec;18(12):2381-2393. doi: 10.1158/1535-7163.MCT-18-0708. Epub 2019 Aug 8.
5
The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data.基于高通量数据的生物信息学分析鉴定鼻咽癌的关键基因。
Mol Biol Rep. 2019 Jun;46(3):2829-2840. doi: 10.1007/s11033-019-04729-3. Epub 2019 Mar 4.
6
A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Cells Cultured in DMEM 10% FBS and Chemically Defined Medium Using Human Adipose-Derived Mesenchymal Stem Cells.基于液相色谱-串联质谱的细胞蛋白质组学分析：用人脂肪间充质干细胞在 DMEM 10% FBS 和化学成分确定的培养基中培养。
Int J Mol Sci. 2018 Jul 13;19(7):2042. doi: 10.3390/ijms19072042.

本文引用的文献

1
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.精氨酸剥夺抑制ASS1缺陷型癌症中的瓦伯格效应并上调谷氨酰胺回补和丝氨酸生物合成。
Cell Rep. 2017 Jan 24;18(4):991-1004. doi: 10.1016/j.celrep.2016.12.077.
2
A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.精氨酸剥夺和氯喹联用的代谢性合成致死策略可导致ASS1缺陷型肉瘤细胞死亡。
Cell Death Dis. 2016 Oct 13;7(10):e2406. doi: 10.1038/cddis.2016.232.
3
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.鉴定一种3-磷酸甘油酸脱氢酶小分子抑制剂以靶向癌症中的丝氨酸生物合成。
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1.
4
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.黑色素瘤细胞中精氨酸脱亚氨酶的抗性与代谢重编程、葡萄糖依赖性和谷氨酰胺成瘾有关。
Mol Cancer Ther. 2013 Nov;12(11):2581-90. doi: 10.1158/1535-7163.MCT-13-0302. Epub 2013 Aug 26.
5
Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer.颠覆细胞代谢：关键糖酵解调控因子 PKM2 在癌症中的新功能。
Trends Biochem Sci. 2012 Aug;37(8):309-16. doi: 10.1016/j.tibs.2012.04.003. Epub 2012 May 23.
6
Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.Ras/PI3K/ERK 通路的激活诱导 c-Myc 稳定，上调精氨酸合成酶，导致黑色素瘤细胞对精氨酸脱氨酶产生抗性。
Cancer Res. 2012 May 15;72(10):2622-33. doi: 10.1158/0008-5472.CAN-11-3605. Epub 2012 Mar 29.
7
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.乳酸脱氢酶 A 的酪氨酸磷酸化对于癌细胞中 NADH/NAD(+) 氧化还原平衡很重要。
Mol Cell Biol. 2011 Dec;31(24):4938-50. doi: 10.1128/MCB.06120-11. Epub 2011 Oct 3.
8
Monitoring phosphorylation of the pyruvate dehydrogenase complex.监测丙酮酸脱氢酶复合体的磷酸化作用。
Anal Biochem. 2009 Jun 15;389(2):157-64. doi: 10.1016/j.ab.2009.03.040. Epub 2009 Mar 31.
9
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.癌症生物学：代谢重编程推动细胞生长和增殖。
Cell Metab. 2008 Jan;7(1):11-20. doi: 10.1016/j.cmet.2007.10.002.
10
In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion.恶性胸膜间皮瘤中精氨琥珀酸合成酶表达的体内缺失是精氨酸耗竭易感性的生物标志物。
Clin Cancer Res. 2006 Dec 1;12(23):7126-31. doi: 10.1158/1078-0432.CCR-06-1101.

在缺乏精氨酸琥珀酸合成酶1（ASS1）的癌症中进行治疗性精氨酸饥饿可抑制瓦伯格效应。

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect.

作者信息

Kremer Jeff C, Van Tine Brian A

机构信息

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Mol Cell Oncol. 2017 Mar 1;4(3):e1295131. doi: 10.1080/23723556.2017.1295131. eCollection 2017.

DOI:10.1080/23723556.2017.1295131
PMID:28616574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5462516/
Abstract

Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

摘要

精氨琥珀酸合成酶1缺乏会导致细胞持续生长和存活依赖细胞外精氨酸。精氨酸饥饿会抑制瓦伯格效应，并将葡萄糖转向丝氨酸生物合成，同时通过三羧酸循环增加谷氨酰胺代谢。同时剥夺精氨酸并抑制随后的代谢适应会诱导合成致死。