在缺乏精氨酸琥珀酸合成酶1（ASS1）的癌症中进行治疗性精氨酸饥饿可抑制瓦伯格效应。
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect.
作者信息
Kremer Jeff C, Van Tine Brian A
机构信息
Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Mol Cell Oncol. 2017 Mar 1;4(3):e1295131. doi: 10.1080/23723556.2017.1295131. eCollection 2017.
Abstract
Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.
摘要
精氨琥珀酸合成酶1缺乏会导致细胞持续生长和存活依赖细胞外精氨酸。精氨酸饥饿会抑制瓦伯格效应，并将葡萄糖转向丝氨酸生物合成，同时通过三羧酸循环增加谷氨酰胺代谢。同时剥夺精氨酸并抑制随后的代谢适应会诱导合成致死。
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