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荷兰40万移民中精神药物的配给情况。

Dispensing of psychotropic medication among 400,000 immigrants in The Netherlands.

作者信息

Termorshuizen Fabian, Selten Jean-Paul, Heerdink Eibert R

机构信息

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.

Rivierduinen, Institute for Mental Health Care, Sandifortdreef 19, 2333 ZZ, Leiden, The Netherlands.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2017 Aug;52(8):963-977. doi: 10.1007/s00127-017-1405-x. Epub 2017 Jun 14.

Abstract

PURPOSE

Previously, a high prevalence of certain psychiatric disorders was shown among non-Western immigrants. This study explores whether this results in more prescriptions for psychotropic medication.

METHODS

Data on dispensing of medication among adults living in the four largest Dutch cities in 2013 were linked to demographic data from Statistics Netherlands. Incident (i.e., following no dispensing in 2010-2012) and prevalent dispensing among immigrants was compared to that among native Dutch (N = 1,043,732) and analyzed using multivariable Poisson and logistic regression.

RESULTS

High adjusted Odds Ratios (OR) of prevalent and high Incidence Rate Ratios (IRR) of incident dispensing of antipsychotics were found among Moroccan (N = 115,455) and Turkish individuals (N = 105,460), especially among young Moroccan males (OR = 3.22 [2.99-3.47]). Among Surinamese (N = 147,123) and Antillean individuals (N = 41,430), slightly higher rates of dispensed antipsychotics were found and the estimates decreased after adjustment. The estimates for antipsychotic dispensing among the Moroccan and Turkish increased, following adjustment for household composition. Rates for antidepressant dispensing among Turkish and Moroccan subjects were high (Moroccans: OR = 1.74 [1.70-1.78]). Among Surinamese and Antillean subjects, the rates for antidepressant dispensing were low and the OR lagged behind the IRR (Surinamese: 0.69 [0.67-0.71] vs. 1.06 [1.00-1.13]). Similar results were found for anxiolytics. For ADHD medication, lower dispensing rates were found among all migrant groups.

CONCLUSIONS

The findings agree with earlier reports of more mental health problems among Moroccan and Turkish individuals. Surinamese/Antillean individuals did not use psychotropic drugs at excess and discontinued antidepressants and anxiolytics earlier. The data strongly suggest under-treatment for ADHD in all ethnic minority groups.

摘要

目的

此前研究表明,某些精神疾病在非西方移民中具有较高的患病率。本研究探讨这是否会导致更多的精神药物处方。

方法

2013年居住在荷兰四大城市的成年人的配药数据与荷兰统计局的人口数据相关联。将移民中的新发(即2010 - 2012年未配药后)和现患配药情况与荷兰本土居民(N = 1,043,732)进行比较,并使用多变量泊松回归和逻辑回归进行分析。

结果

在摩洛哥人(N = 115,455)和土耳其人(N = 105,460)中,发现抗精神病药物现患的调整后优势比(OR)较高,新发配药的发病率比(IRR)也较高,尤其是在年轻的摩洛哥男性中(OR = 3.22 [2.99 - 3.47])。在苏里南人(N = 147,123)和安的列斯群岛人(N = 41,430)中,发现抗精神病药物的配药率略高,调整后估计值有所下降。在调整家庭构成后,摩洛哥人和土耳其人抗精神病药物配药的估计值有所增加。土耳其和摩洛哥受试者的抗抑郁药物配药率较高(摩洛哥人:OR = 1.74 [1.70 - 1.78])。在苏里南人和安的列斯群岛人中,抗抑郁药物的配药率较低,OR落后于IRR(苏里南人:0.69 [0.67 - 0.71] 对 1.06 [1.00 - 1.13])。抗焦虑药物也有类似结果。对于注意力缺陷多动障碍(ADHD)药物,所有移民群体的配药率较低。

结论

研究结果与早期关于摩洛哥人和土耳其人心理健康问题较多的报道一致。苏里南人/安的列斯群岛人并未过度使用精神药物,且较早停用抗抑郁药和抗焦虑药。数据强烈表明所有少数民族群体中ADHD的治疗不足。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e84/5534199/2e42d9a4f6e3/127_2017_1405_Fig1_HTML.jpg

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