Monteiro Júnior F C, Mandarino N R, Santos E M, Santos A M, Salgado J V, Brito D J A, Salgado B J L, Lages J S, Castelo Branco G, Salgado Filho N
Serviço de Cardiologia, Universidade Federal do Maranhão, São Luís, MA, Brasil.
Departamento de Enfermagem, Universidade Federal do Maranhão, São Luís, MA, Brasil.
Braz J Med Biol Res. 2018;51(4):e7185. doi: 10.1590/1414-431x20177185. Epub 2018 Feb 26.
Hypovitaminosis D has been identified as a possible new cardiovascular risk factor. However, the results of studies correlating serum vitamin D levels with markers of subclinical atherosclerosis have been conflicting. The aim of this study was to correlate serum levels of 25-hydroxyvitamin D [25(OH)D] with carotid intima-media thickness (C-IMT) and conventional cardiovascular risk factors in Afro-descendants. A cross-sectional analysis was performed on a sample of 382 individuals from a cohort of descendants of African slaves, inhabitants of "Quilombola" communities, with a mean age of 57.79 ±15.3 years, 54.5% of whom were women. Socio-demographic and clinical data were collected and biochemical tests were performed, including serum levels of 25(OH)D by electrochemiluminescence and urinary albumin excretion, evaluated by the albumin/creatinine ratio (ACR) in a spot urine sample. All participants underwent high-resolution ultrasonography for C-IMT measurement. Hypovitaminosis D was defined as serum 25(OH)D levels <30 ng/mL. The mean serum 25(OH)D levels were 50.4±13.5 ng/mL, with a low prevalence of hypovitaminosis D (4.86%). By simple linear correlation, a significant inverse association between 25(OH)D levels and C-IMT (r=-0.174, P=0.001) was observed. However, after multiple linear regression analysis, the significance of the association between serum levels of 25(OH)D and C-IMT measurement was lost (β=-0.039, P=0.318) and only male gender, age, smoking, systolic blood pressure, glucose and low density lipoprotein (LDL)-cholesterol remained significantly associated with C-IMT. Levels of 25(OH)D were independently and positively associated with HDL-cholesterol and inversely associated with age and ACR. In conclusion, no independent association between 25(OH)D levels and C-IMT was observed in this population. On the other hand, there was an inverse association with albuminuria, a marker of endothelial lesion.
维生素D缺乏已被确认为一种可能的新型心血管危险因素。然而，关于血清维生素D水平与亚临床动脉粥样硬化标志物之间相关性的研究结果一直存在矛盾。本研究的目的是探讨非洲裔人群血清25-羟基维生素D[25(OH)D]水平与颈动脉内膜中层厚度（C-IMT）及传统心血管危险因素之间的相关性。对来自非洲奴隶后裔队列、居住在“基隆波拉”社区的382名个体进行了横断面分析，他们的平均年龄为57.79±15.3岁，其中54.5%为女性。收集了社会人口学和临床数据，并进行了生化检测，包括通过电化学发光法检测血清25(OH)D水平以及通过即时尿样中的白蛋白/肌酐比值（ACR）评估尿白蛋白排泄情况。所有参与者均接受了高分辨率超声检查以测量C-IMT。维生素D缺乏定义为血清25(OH)D水平<30 ng/mL。血清25(OH)D的平均水平为50.4±13.5 ng/mL，维生素D缺乏的患病率较低（4.86%）。通过简单线性相关分析，观察到25(OH)D水平与C-IMT之间存在显著的负相关（r=-0.174，P=0.001）。然而，经过多元线性回归分析后，25(OH)D血清水平与C-IMT测量值之间的相关性不再显著（β=-0.039，P=0.318），只有男性、年龄、吸烟、收缩压、血糖和低密度脂蛋白（LDL）胆固醇仍与C-IMT显著相关。25(OH)D水平与高密度脂蛋白胆固醇呈独立正相关，与年龄和ACR呈负相关。总之，在该人群中未观察到25(OH)D水平与C-IMT之间存在独立相关性。另一方面，与作为内皮损伤标志物的蛋白尿呈负相关。
