小金灯笼中的抗炎和细胞毒性甾体生物碱。
Anti-inflammatory and cytotoxic withanolides from Physalis minima.
机构信息
College of Pharmaceutical Science, Bozhou Vocational and Technical College, Bozhou, 236800, China; College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.
Department I of Pharmacology, Clinical Pharmacology, Cologne University Hospital, Cologne, 50931, Germany.
出版信息
Phytochemistry. 2018 Nov;155:164-170. doi: 10.1016/j.phytochem.2018.08.009. Epub 2018 Aug 17.
Six undescribed withanolides were isolated and characterized during the investigation of anti-inflammatory and cytotoxic constituents from the whole plants of Physalis minima L. Their structures were elucidated by extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR), and their anti-inflammatory and cytotoxic activities were evaluated in vitro. All the compounds exhibited anti-inflammatory ability via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Moderate cytotoxic activities against A549 lung adenocarcinoma cells, SMMC-7721 hepatic carcinoma cells and MCF-7 breast cancer cells with IC values in the range of 40.01-82.17 μM were observed for these withanolides.
在对小酸浆全植物的抗炎和细胞毒性成分进行研究时，分离并鉴定了 6 种未被描述的醉茄内酯。通过广泛的光谱分析（IR、UV、HR-ESI-MS、1D-NMR 和 2D-NMR）阐明了它们的结构，并在体外评估了它们的抗炎和细胞毒性活性。所有化合物均通过抑制脂多糖（LPS）刺激的小鼠巨噬细胞 RAW 264.7 细胞中一氧化氮（NO）的产生表现出抗炎能力。这些醉茄内酯对 A549 肺腺癌细胞、SMMC-7721 肝癌细胞和 MCF-7 乳腺癌细胞具有中度细胞毒性活性，IC 值范围为 40.01-82.17 μM。
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