Miloudi H, Locatelli M, Autret G, Balvay D, Desbree A, Blanchardon E, Bertho J M
Institut de radioprotection et de sûreté nucléaire (IRSN), PRP-HOM/SDI/LEDI, Fontenay-aux-roses, France.
J Radiol Prot. 2017 Sep 25;37(3):564-583. doi: 10.1088/1361-6498/aa6732. Epub 2017 Jun 15.
H Miloudi, M Locatelli, G Autret, D Balvay, A Desbrée, E Blanchardon, J M Bertho: application of RODES software to experimental biokinetic data for dose assessment in mice and rats. In support of experimental studies of chronic, long-term contamination in rodents, voxel-based computer models were built representing adult mice and juvenile, adult and elderly rats of both sexes. RODES software was created to calculate absorbed radiation doses to organs with these specific anatomical models. Absorbed doses were then calculated starting from previously published biokinetic data. Whole body doses showed less than 5% differences between calculation with RODES and calculation with the ICRP Publication 108 model for long term exposure to Sr of mice. Similar results were obtained for long term exposure to Cs. Dose distribution for Sr internal contamination also showed that the dose to the skeleton is six fold more as compared to the whole body dose while radiation dose to other organs is less than the mean whole body dose. These results underline the importance of using specific anatomical models according to the age and the sex of experimental animals.
H·米卢迪、M·洛卡特利、G·奥特尔、D·巴尔维、A·德布雷、E·布兰沙尔东、J·M·贝托：RODES软件在小鼠和大鼠剂量评估实验生物动力学数据中的应用。为支持对啮齿动物慢性、长期污染的实验研究，构建了基于体素的计算机模型，分别代表成年小鼠以及雌雄幼龄、成年和老年大鼠。创建RODES软件是为了利用这些特定的解剖模型计算器官的吸收辐射剂量。然后根据先前发表的生物动力学数据计算吸收剂量。对于长期暴露于锶的小鼠，全身剂量在使用RODES计算和使用国际辐射防护委员会第108号出版物模型计算之间的差异小于5%。对于长期暴露于铯的情况也获得了类似结果。锶内污染的剂量分布还表明，骨骼所受剂量比全身剂量高六倍，而其他器官的辐射剂量低于全身平均剂量。这些结果强调了根据实验动物的年龄和性别使用特定解剖模型的重要性。
