Mozafari M R, Javanmard R, Raji M
Australasian Nanoscience and Nanotechnology Initiative, Clayton, 3168 Victoria, Australia.
Australasian Nanoscience and Nanotechnology Initiative, Clayton, 3168 Victoria, Australia.
Int J Pharm. 2017 Aug 7;528(1-2):381-382. doi: 10.1016/j.ijpharm.2017.06.037. Epub 2017 Jun 12.
The potential of two derivatives of vitamin E, i.e. α-tocopheryl phosphate (TP) and di-α-tocopheryl phosphate (TP), for the protection and delivery of therapeutics is being investigated in our laboratory and some promising results have been obtained so far. Novel nanocarrier systems containing TP, TP and different lipids/phospholipids (phosphatidylcholine, stearyl amine, Phospholipon 90H, Phospholipon 100H) with and without cholesterol were prepared using Mozafari method. The preparation method did not require utilization of potentially toxic solvents, detergents or employment of harsh treatments such as sonication or high-shear force homogenization. Tocosomes, containing 5-fluorouracil (as a model drug), were shown to possess narrow size distribution, acceptable encapsulation efficiency and long-term stability (more than two years).
我们实验室正在研究维生素E的两种衍生物，即α-生育酚磷酸酯（TP）和二-α-生育酚磷酸酯（TP）在治疗药物保护和递送方面的潜力，目前已取得了一些有前景的结果。采用莫扎法里方法制备了含有TP、TP以及不同脂质/磷脂（磷脂酰胆碱、硬脂胺、磷脂90H、磷脂100H）且有无胆固醇的新型纳米载体系统。该制备方法无需使用潜在有毒的溶剂、洗涤剂，也无需采用诸如超声处理或高剪切力均质化等严苛处理。含有5-氟尿嘧啶（作为模型药物）的囊泡显示出具有窄尺寸分布、可接受的包封效率和长期稳定性（超过两年）。
