Atrooz Omar, Kerdari Elham, Mozafari M R, Reihani Nasim, Asadi Ali, Torkaman Sarabanou, Alavi Mehran, Taghavi Elham
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
Department of Biological Sciences, Mutah University, Mutah 61710, Jordan.
Biomedicines. 2024 Sep 3;12(9):2002. doi: 10.3390/biomedicines12092002.
Contemporary nutraceutical and biomedical sectors are witnessing fast progress in efficient product development due to the advancements in nanoscience and encapsulation technology. Nutraceuticals are generally defined as food substances, or a section thereof, that provide us with health benefits such as disease prevention and therapy. Nutraceutical and biomedical compounds as well as food supplements are a natural approach for attaining therapeutic outcomes with negligible or ideally no adverse effects. Nonetheless, these materials are susceptible to deterioration due to exposure to heat, oxygen, moisture, light, and unfavorable pH values. Tocosomes, or bilayered lyotropic vesicles, are an ideal encapsulation protocol for the food and nutraceutical industries. Biocompatibility, high entrapment capacity, storage stability, improved bioavailability, site specific delivery, and sustained-release characteristics are among the advantages of this nanocarrier. Similar to liposomal carriers and nanoliposomes, tocosomes are able to encapsulate hydrophilic and hydrophobic compounds separately or simultaneously, offering synergistic bioactive delivery. This manuscript describes different aspects of tocosome in parallel to liposome and nanoliposome technologies pertaining to nutraceutical and nanonutraceutical applications. Different properties of these nanocarriers, such as their physicochemical characteristics, preparation approaches, targeting mechanisms, and their applications in the biomedical and nutraceutical industries, are also covered.
由于纳米科学和包封技术的进步，当代营养保健品和生物医学领域在高效产品开发方面正取得快速进展。营养保健品通常被定义为能给我们带来诸如疾病预防和治疗等健康益处的食品物质或其一部分。营养保健品、生物医学化合物以及食品补充剂是实现治疗效果且副作用可忽略不计或理想情况下无副作用的天然方法。然而，这些物质因暴露于热、氧气、水分、光线和不利的pH值而容易变质。生育酚体，即双层溶致液晶囊泡，是食品和营养保健品行业理想的包封方案。这种纳米载体的优点包括生物相容性、高包封能力、储存稳定性、提高的生物利用度、位点特异性递送和缓释特性。与脂质体载体和纳米脂质体类似，生育酚体能够分别或同时包封亲水性和疏水性化合物，实现协同生物活性递送。本手稿描述了生育酚体在与脂质体和纳米脂质体技术并行的营养保健品和纳米营养保健品应用方面的不同方面。还涵盖了这些纳米载体的不同特性，如它们的物理化学特征、制备方法、靶向机制以及它们在生物医学和营养保健品行业的应用。
