Department of Emergency, The First Hospital of Jilin University, Changchun, 130021, China.
Dermatology Department, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Sci Rep. 2017 Jun 15;7(1):3556. doi: 10.1038/s41598-017-03856-w.
Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role of IL-28B in inducing type 1 immunity and protecting against ovalbumin (OVA)-induced allergic asthma in mice. IL-28B overexpression in wild-type mice promoted natural killer (NK) cell polarization in the lung, leading to the increased number of interferon (IFN)-γ-producing NK1 cells as well as Th1 differentiation. Importantly, IL-28B overexpression had no protective effect on OVA-induced asthma in IFN-γ-knockout (IFN-γ-/-) mice. These results demonstrate that IL-28B ameliorates experimental allergic asthma via enhancing NK cell polarization, which might be useful for prevention and treatment of allergic asthma.
白细胞介素-28A（IL-28A）调节 CD11c+树突状细胞（DC）功能，促进 1 型 T 辅助（Th1）分化，从而抑制过敏性气道疾病。然而，IL-28A 同种型 IL-28B 在这些疾病中的功能在很大程度上仍然未知。在这项研究中，我们揭示了 IL-28B 在诱导 1 型免疫和保护小鼠卵清蛋白（OVA）诱导的过敏性哮喘中的新作用。在野生型小鼠中过表达 IL-28B 可促进肺中自然杀伤（NK）细胞的极化，导致 IFN-γ 产生的 NK1 细胞数量增加以及 Th1 分化。重要的是，IL-28B 过表达对 IFN-γ 敲除（IFN-γ-/-）小鼠的 OVA 诱导的哮喘没有保护作用。这些结果表明，IL-28B 通过增强 NK 细胞极化来改善实验性过敏性哮喘，这可能有助于预防和治疗过敏性哮喘。
