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柳叶红千层中的细胞毒性酰基间苯三酚衍生物。

Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.

作者信息

Qin Xu-Jie, Shu Tong, Yu Qian, Yan Huan, Ni Wei, An Lin-Kun, Li Pan-Pan, Zhi Yin-E, Khan Afsar, Liu Hai-Yang

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

Yunnan Key Laboratory of Medicinal Chemistry, Kunming, 650201, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2017 Aug;7(4):315-321. doi: 10.1007/s13659-017-0138-6. Epub 2017 Jun 15.

DOI:10.1007/s13659-017-0138-6
PMID:28620873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5507812/
Abstract

Callisalignenes G-I (1-3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.

摘要

从柳叶红千层中分离得到了Callisalignenes G-I（1-3），三种新的β-三酮和单萜类杂萜，以及两种已知类似物（4和5）。通过核磁共振（NMR）、质谱（MS）分析以及电子圆二色光谱（ECD）证据相结合，明确确定了它们的结构和绝对构型。Callisalignenes H（2）和I（3）在C-7位具有罕见的仲丁基部分。杂萜1-3对HCT116细胞表现出细胞毒性，IC值分别为8.51±1.8、9.12±0.3和16.33±3.3μM。来自柳叶红千层的细胞毒性酰基间苯三酚衍生物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/7714eb41ab16/13659_2017_138_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/88c169e3ee4f/13659_2017_138_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/190c91acf958/13659_2017_138_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/7714eb41ab16/13659_2017_138_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/88c169e3ee4f/13659_2017_138_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/190c91acf958/13659_2017_138_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26b/5507812/7714eb41ab16/13659_2017_138_Fig3_HTML.jpg

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