Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China.
Fitoterapia. 2022 Sep;161:105251. doi: 10.1016/j.fitote.2022.105251. Epub 2022 Jul 6.
Three novel geranylhydroquinone derived meroterpenoids, named clavilactones J and K (1-2) and clavipol C (3), were isolated from the basidiomycete Clitocybe clavipes. Their structures were unambiguously identified by extensive spectroscopic data analysis, and the electronic circular dichroism (ECD) calculation, Gauge-Including Atomic Orbitals (GIAO) NMR calculations and Mo(OAc)-induced electronic circular dichroism experiments were used to establish their absolute configurations. Compound 1, with two epoxy groups located at the 10-membered carbocycle, is uncommon in the reported meroterpenoids from C. clavipes. All the obtained compounds (1-3) were tested for their cytotoxic activity against human tumor cell line HGC-27 by using the MTT assay. All the compounds exhibited moderate cytotoxic activities against HGC-27 cell with IC values ranging from 33.5 to 56.6 μM.
三种新型的香叶基氢醌衍生的混合萜类化合物，命名为clavilactones J 和 K（1-2）和clavipol C（3），从担子菌 Clitocybe clavipes 中分离得到。通过广泛的光谱数据分析以及电子圆二色性（ECD）计算、Gauge-Including Atomic Orbitals（GIAO）NMR 计算和 Mo(OAc)-诱导的电子圆二色性实验，确定了它们的绝对构型。化合物 1 具有两个环氧基团位于 10 元碳环上，在从 C. clavipes 中报道的混合萜类化合物中并不常见。所有获得的化合物（1-3）均通过 MTT 法测试对人肿瘤细胞系 HGC-27 的细胞毒性。所有化合物对 HGC-27 细胞均显示出中等的细胞毒性活性，IC 值范围为 33.5 至 56.6 μM。
