青光眼眼中房水的炎症细胞因子的特征谱。

Characteristic Profiles of Inflammatory Cytokines in the Aqueous Humor of Glaucomatous Eyes.

机构信息

a Department of Ophthalmology , Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai , Japan.

b Department of Retinal Disease Control , Ophthalmology, Tohoku University Graduate School of Medicine , Sendai , Japan.

出版信息

Ocul Immunol Inflamm. 2018;26(8):1177-1188. doi: 10.1080/09273948.2017.1327605. Epub 2017 Jun 16.

DOI:10.1080/09273948.2017.1327605

PMID:28622063

Abstract

PURPOSE

To analyze cytokine profiles of the aqueous humor of eyes with primary open-angle glaucoma (POAG), neovascular glaucoma (NVG), and cataract (as controls).

METHODS

A multiplex bead assay was used to measure concentrations of 27 cytokines in aqueous humor samples from 54 eyes.

RESULTS

Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower than cataract or NVG; and GM-CSF: cataract higher than POAG or NVG. Concentrations were as follows: IL-8, IP-10, MCP-1, and MIP-1β: POAG and NVG higher than cataract; IL-9: POAG lower than NVG; IL-12: POAG lower than cataract or NVG; and VEGF: NVG higher than cataract or POAG and POAG lower than cataract. Further analysis showed that IL-8, IP-10, MCP-1, and MIP-1β were correlated with intraocular pressure and age.

CONCLUSIONS

The detection rates and levels of various cytokines had different patterns in POAG and NVG patients, suggesting distinctive alterations in the microenvironment in different types of glaucoma.

摘要

目的

分析原发性开角型青光眼（POAG）、新生血管性青光眼（NVG）和白内障（作为对照）眼房水中的细胞因子谱。

方法

使用多重微珠检测法测量 54 只眼中房水样本中 27 种细胞因子的浓度。

结果

检测到的细胞因子如下：IL-7：NVG 高于 POAG；IL-10：POAG 低于白内障或 NVG；GM-CSF：白内障高于 POAG 或 NVG。浓度如下：IL-8、IP-10、MCP-1 和 MIP-1β：POAG 和 NVG 高于白内障；IL-9：POAG 低于 NVG；IL-12：POAG 低于白内障或 NVG；VEGF：NVG 高于白内障或 POAG，POAG 低于白内障。进一步分析表明，IL-8、IP-10、MCP-1 和 MIP-1β 与眼内压和年龄相关。