Rainsford K D
J Pharm Pharmacol. 1985 May;37(5):341-5. doi: 10.1111/j.2042-7158.1985.tb05078.x.
Methods are described for the HPLC determination of azapropazone and its 8-hydroxyl metabolite in plasma, urine and gastrointestinal mucosae after purification of samples on reverse-phase mini columns. Plasma levels of the drug in gouty patients receiving 900-2400 mg daily were relatively constant after 5 days, though overall the values were higher than after a single dose. Gastric absorption of azapropazone in rats is relatively rapid suggesting that the low gastric irritancy is probably due to its weak inhibitory effects on prostaglandin and mucus synthesis rather than slow gastric absorption.
描述了在反相微型柱上对样品进行净化后，用高效液相色谱法测定血浆、尿液和胃肠道黏膜中阿扎丙宗及其8-羟基代谢物的方法。接受每日900 - 2400 mg剂量的痛风患者，5天后血浆中的药物水平相对稳定，不过总体数值高于单次给药后。阿扎丙宗在大鼠体内的胃吸收相对较快，这表明其低胃刺激性可能是由于对前列腺素和黏液合成的抑制作用较弱，而非胃吸收缓慢。
