Kasprowska-Liśkiewicz Daniela, Liśkiewicz Arkadiusz D, Nowacka-Chmielewska Marta M, Nowicka Joanna, Małecki Andrzej, Barski Jarosław J
Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland; Department of Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland; Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Physiol Behav. 2017 Oct 1;179:168-177. doi: 10.1016/j.physbeh.2017.06.007. Epub 2017 Jun 13.
The positive effects of the ketogenic diet (KD) on social behavior have been recently reported in patients and rodent models of autism spectrum disorder (ASD). Given the beneficial effects of the KD on epilepsy, mitochondrial function, carbohydrate metabolism, and inflammation, treatment based on the KD has the potential to reduce some of the ASD-associated symptoms, including abnormal social interactions. It is not known whether the KD influences sociability by reducing the pathological processes underlying ASD or through some independent mechanism. The aim of the present study was to evaluate the influence of the KD on the social behavior of rats. Four-week-old Long-Evans males were treated with the KD for 4 subsequent weeks. Afterwards, behavioral tests were performed in order to evaluate sociability, locomotor activity, working memory, and anxiety-related behaviors. Additionally we performed the social interaction test in animals that were receiving β-hydroxybutyrate or acetone. We have observed that rats fed with the KD showed increased social exploration in three different experimental settings. We did not observe any changes in the level of social interactions in animals treated with exogenous ketone bodies. The results did not show any difference in mobility or anxiety-related behaviors or working memory between the animals fed with the KD or standard rodent chow. In conclusion, we showed that the KD affects the social behavior of wild-type young adult male rats, which was not associated with other behavioral changes.
最近有报道称，生酮饮食（KD）对自闭症谱系障碍（ASD）患者和啮齿动物模型的社交行为具有积极影响。鉴于KD对癫痫、线粒体功能、碳水化合物代谢和炎症的有益作用，基于KD的治疗有可能减轻一些与ASD相关的症状，包括异常的社交互动。目前尚不清楚KD是通过减少ASD潜在的病理过程还是通过某种独立机制来影响社交能力。本研究的目的是评估KD对大鼠社交行为的影响。对四周龄的Long-Evans雄性大鼠连续四周给予KD治疗。之后，进行行为测试以评估社交能力、运动活动、工作记忆和焦虑相关行为。此外，我们在接受β-羟基丁酸或丙酮的动物中进行了社交互动测试。我们观察到，喂食KD的大鼠在三种不同的实验环境中表现出增加的社交探索行为。我们没有观察到用外源性酮体处理的动物在社交互动水平上有任何变化。结果显示，喂食KD的动物与喂食标准啮齿动物饲料的动物在运动能力、焦虑相关行为或工作记忆方面没有任何差异。总之，我们表明KD会影响野生型成年雄性大鼠的社交行为，且这与其他行为变化无关。
