Farrag Nourihan S, El-Sabagh Hanan A, Al-Mahallawi Abdulaziz M, Amin Abeer M, AbdEl-Bary Ahmed, Mamdouh Wael
Labeled Compounds Department, Hot Labs Center, Atomic Energy Authority, Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Int J Pharm. 2017 Aug 30;529(1-2):123-133. doi: 10.1016/j.ijpharm.2017.06.044. Epub 2017 Jun 15.
A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time. The reported highly efficient method provides new radiolabeled Ag-based NPs as tumor-specific agents for both diagnostic and therapeutic applications.
已使用碘同位素对三种类型的银纳米颗粒进行放射性标记，该方法简单快速，标记产率高，大于90%，且不影响光学性质。研究了影响标记产率的所有因素。为了利用γ射线监测放射性标记银纳米颗粒在体内的组织摄取情况，将标记产率最高的基于银的放射性碘纳米颗粒静脉注射到正常小鼠和荷实体瘤小鼠体内。初步的生物分布研究表明，这种新型放射性碘纳米颗粒具有高亲和力，可长时间定位于肿瘤部位。所报道的高效方法提供了新型放射性标记的基于银的纳米颗粒，作为用于诊断和治疗应用的肿瘤特异性药物。
