血小板分布宽度较高预示喉癌预后不良。
Higher platelet distribution width predicts poor prognosis in laryngeal cancer.
作者信息
Zhang Huan, Liu Li, Fu Shuang, Liu Yan-Song, Wang Changsong, Liu Tiemin, Liu Zhi-Ping, Wang Rui-Tao, Yu Kai-Jiang
机构信息
Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
出版信息
Oncotarget. 2017 Jul 18;8(29):48138-48144. doi: 10.18632/oncotarget.18306.
BACKGROUND
Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer.
RESULTS
Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001).
METHOD
The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW.
CONCLUSIONS
Elevated PDW might be a novel prognostic marker in laryngeal cancer.
背景
活化血小板促进癌症进展和转移。然而，血小板指标在喉癌中的预后价值仍知之甚少。本研究旨在探讨血小板指标在喉癌中的预测意义。
结果
241例患者中，116例（48.1%）患者血小板分布宽度（PDW）水平较高。在Kaplan-Meier分析中，PDW升高与较差的总生存期显著相关（p < 0.001）。在多变量Cox模型中，PDW是总生存期的独立预后指标（HR=4.381，95%CI=2.313-8.298，P < 0.001）。
方法
回顾性研究纳入了2009年1月至2009年12月期间连续的241例喉癌患者。分析了PDW与临床病理特征之间的关系。采用Kaplan-Meier法和Cox回归评估PDW的预后影响。
结论
PDW升高可能是喉癌的一种新的预后标志物。
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