Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Emergency Surgery, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Cancer Biomark. 2019;24(3):307-313. doi: 10.3233/CBM-182076.
Previous studies have demonstrated that platelets play an important role in growth, invasion, and angiogenesis of a variety of tumors. Nevertheless, the prognostic role of platelet indices in hepatocellular carcinoma (HCC) has not been explored. The aim of this study was to explore the association between platelet indices and prognosis in HCC.
A total of 260 patients with HCC between January 2009 and December 2015 were retrospectively analyzed. The optimal platelet distribution width (PDW) cutoff value is identified by the receiver operating characteristic curve (ROC) curve. The relationship between PDW and clinicopathological features was assessed. The prognostic effects of PDW were assessed by using the Kaplan-Meier method and Cox regression model.
Elevated PDW level was significantly associated with portal hypertension, vascular invasion, and Child-Pugh grade. In addition, survival curve indicates that patients with high PDW levels have a worse prognosis than patients with low PDW levels (P< 0.001). Multivariate Cox regression analysis identified PDW as an independent factor of prognosis in HCC patients (hazard ratio: 4.460, 95% confidence interval: 2.308-8.619, P< 0.001).
Elevated PDW may be a novel marker for predicting the prognosis of HCC, but further research is needed to validate our conclusions.
先前的研究表明，血小板在多种肿瘤的生长、侵袭和血管生成中发挥着重要作用。然而，血小板指标在肝细胞癌（HCC）中的预后作用尚未得到探索。本研究旨在探讨血小板指标与 HCC 预后之间的关系。
回顾性分析了 2009 年 1 月至 2015 年 12 月期间的 260 例 HCC 患者。通过接受者操作特征曲线（ROC）曲线确定最佳血小板分布宽度（PDW）截断值。评估 PDW 与临床病理特征之间的关系。采用 Kaplan-Meier 法和 Cox 回归模型评估 PDW 的预后影响。
升高的 PDW 水平与门静脉高压、血管侵犯和 Child-Pugh 分级显著相关。此外，生存曲线表明，PDW 水平较高的患者预后较 PDW 水平较低的患者差（P<0.001）。多因素 Cox 回归分析确定 PDW 是 HCC 患者预后的独立因素（风险比：4.460，95%置信区间：2.308-8.619，P<0.001）。
升高的 PDW 可能是预测 HCC 预后的一个新标志物，但需要进一步研究来验证我们的结论。
