Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Drug Discov Today. 2017 Oct;22(10):1503-1515. doi: 10.1016/j.drudis.2017.06.001. Epub 2017 Jun 16.
The tumor vasculature transports oxygen, nutrients and drugs for crucial roles in tumor therapy. Antivascular therapy directly targets existing tumor vessels to reduce blood perfusion and then inhibit tumor growth. Vascular disrupting agents and ultrasound-stimulated microbubble destruction use chemical toxicity and physical effect, respectively, to damage vascular endothelial cells for antivascular therapy. Moreover, antivascular therapy can break vessel wall barriers and change the tumor microenvironment to compensate for the limitations of conventional chemotherapy or radiotherapy. This review presents current progress and an overview of antivascular therapy, which can inform the development and application in cancer research.
肿瘤血管为肿瘤治疗中的重要作用运输氧气、营养物质和药物。抗血管治疗直接针对现有肿瘤血管，减少血液灌注，从而抑制肿瘤生长。血管破坏剂和超声刺激的微泡破坏分别利用化学毒性和物理效应来破坏血管内皮细胞以进行抗血管治疗。此外，抗血管治疗可以打破血管壁屏障并改变肿瘤微环境，以弥补传统化疗或放疗的局限性。本综述介绍了抗血管治疗的最新进展和概述，可为癌症研究中的开发和应用提供信息。
