Burgos-Aceves Mario Alberto, Faggio Caterina
Centro de Investigaciones Biológicas de Noroeste, S.C., Mar Bermejo 195, Col. Playa Palo de Sta. Rita, La Paz, BCS 23090, Mexico.
Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres, 31, 98166 Messina, Italy.
Fish Shellfish Immunol. 2017 Aug;67:513-517. doi: 10.1016/j.fsi.2017.06.042. Epub 2017 Jun 16.
The Mediterranean mussel Mytilus galloprovincialis is an ecologically and economically important species. It has been used in programs of monitoring of pollution, since it is sessile organism that is capable of accumulating pollutants in tissues through filter feeding. Due to an increase of pollutants in the environment, marine mussels present physiological alterations that compromise their innate immune system, which can latter lead to opportunistic diseases. The haemocytes are the cells in charge of the immune response in the Mediterranean mussel and in other mollusks. In this review, we summarize the physiological and genetic response capacity of these immune cells to the presence of xenobiotics, pathogens and the interplay. The identification of the basic mechanisms of immunity and their modulation in mussels can give important information for the possible utilization of this species as an invertebrate model for studies on innate immunity, future immunotoxicological studies, and predict changes in the community for the future.
地中海贻贝（Mytilus galloprovincialis）是一种在生态和经济方面都很重要的物种。它已被用于污染监测项目，因为它是一种固着生物，能够通过滤食在组织中积累污染物。由于环境中污染物的增加，海洋贻贝出现了生理变化，这损害了它们的先天免疫系统，进而可能导致机会性疾病。血细胞是负责地中海贻贝和其他软体动物免疫反应的细胞。在这篇综述中，我们总结了这些免疫细胞对外源生物、病原体及其相互作用的生理和遗传反应能力。确定贻贝免疫的基本机制及其调节方式，可以为将该物种用作研究先天免疫的无脊椎动物模型、未来的免疫毒理学研究以及预测未来群落变化提供重要信息。
