Themis2: setting the threshold for B-cell selection.
作者信息
Deobagkar-Lele Mukta, Anzilotti Consuelo, Cornall Richard J
机构信息
MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
出版信息
Cell Mol Immunol. 2017 Aug;14(8):643-645. doi: 10.1038/cmi.2017.27. Epub 2017 Jun 19.
Abstract
摘要
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本文引用的文献
1
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.THEMIS增强TCR信号传导，并通过选择性抑制磷酸酶SHP-1实现阳性选择。
Nat Immunol. 2017 Apr;18(4):433-441. doi: 10.1038/ni.3692. Epub 2017 Feb 27.
2
Themis2 lowers the threshold for B cell activation during positive selection.Themis2 降低了阳性选择过程中 B 细胞活化的阈值。
Nat Immunol. 2017 Feb;18(2):205-213. doi: 10.1038/ni.3642. Epub 2016 Dec 19.
3
Themis2 is not required for B cell development, activation, and antibody responses.Themis2对于B细胞的发育、激活及抗体反应并非必需。
J Immunol. 2014 Jul 15;193(2):700-7. doi: 10.4049/jimmunol.1400943. Epub 2014 Jun 6.
4
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.单克隆 BCR 交联激活卵清蛋白特异性跨核 B 细胞。
J Exp Med. 2014 Feb 10;211(2):365-79. doi: 10.1084/jem.20131603. Epub 2014 Feb 3.
5
Themis sets the signal threshold for positive and negative selection in T-cell development.Themis 为 T 细胞发育中的阳性选择和阴性选择设定信号阈值。
Nature. 2013 Dec 19;504(7480):441-5. doi: 10.1038/nature12718. Epub 2013 Nov 13.
6
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.Themis1 和 Themis2 在胸腺细胞发育中的可互换性揭示了两种具有保守分子功能的相关蛋白。
J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25.
7
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.Gasp是一种与Grb2相关的蛋白质，对胸腺细胞的阳性选择至关重要。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16345-50. doi: 10.1073/pnas.0908593106. Epub 2009 Sep 14.
8
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.忒弥斯通过调节T细胞抗原受体介导的信号传导来控制胸腺细胞的选择。
Nat Immunol. 2009 Aug;10(8):848-56. doi: 10.1038/ni.1766. Epub 2009 Jul 13.
9
Themis, a T cell-specific protein important for late thymocyte development.Themis是一种对晚期胸腺细胞发育很重要的T细胞特异性蛋白。
Nat Immunol. 2009 Aug;10(8):840-7. doi: 10.1038/ni.1768. Epub 2009 Jul 13.
10
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.Themis是一个新的后生动物基因家族的成员，是胸腺细胞阳性选择完成所必需的。
Nat Immunol. 2009 Aug;10(8):831-9. doi: 10.1038/ni.1769. Epub 2009 Jul 13.
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