Shaw Michael T, Pawlak Natalie O, Frontario Ariana, Sherman Kathleen, Krupp Lauren B, Charvet Leigh E
Department of Neurology, NYU Langone Medical Center, New York, NY, United States.
Lake Erie College of Osteopathic Medicine, Erie, PA, United States.
Front Neurol. 2017 Jun 2;8:242. doi: 10.3389/fneur.2017.00242. eCollection 2017.
Adverse childhood experiences (ACEs) exert a psychological and physiological toll that increases risk of chronic conditions, poorer social functioning, and cognitive impairment in adulthood.
To investigate the relationship between childhood adversity and clinical disease features in multiple sclerosis (MS).
Sixty-seven participants with MS completed the ACE assessment and neuropsychological assessments as part of a larger clinical trial of cognitive remediation.
Adverse childhood experience scores, a measure of exposure to adverse events in childhood, significantly predicted age of MS onset ( = -0.30, = 0.04). ACEs were also linked to reading recognition (a proxy for premorbid IQ) ( = -0.25, = 0.04). ACE scores were not related to age, current disability, or current level of cognitive impairment measured by the Symbol Digit Modalities Test (SDMT).
Childhood adversity may increase the likelihood of earlier age of onset and poorer estimated premorbid IQ in MS.
童年不良经历（ACEs）会对心理和生理造成损害，增加成年后患慢性病、社会功能较差和认知障碍的风险。
研究童年逆境与多发性硬化症（MS）临床疾病特征之间的关系。
作为一项更大规模的认知康复临床试验的一部分，67名MS患者完成了ACE评估和神经心理学评估。
童年不良经历得分是衡量童年时期不良事件暴露程度的指标，显著预测了MS发病年龄（r = -0.30，P = 0.04）。ACEs还与阅读识别能力（病前智商的一个指标）相关（r = -0.25，P = 0.04）。ACE得分与年龄、当前残疾程度或通过符号数字模态测试（SDMT）测量的当前认知障碍水平无关。
童年逆境可能会增加MS发病年龄较早和病前智商估计较差的可能性。
