Piana Mariana, Camponogara Camila, Boligon Aline Augusti, Oliveira Sara Marchesan
Laboratório de Análises Fitoquímicas, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil.
Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil.
Evid Based Complement Alternat Med. 2017;2017:4295680. doi: 10.1155/2017/4295680. Epub 2017 May 24.
The aim of the study was to evaluate the anti-inflammatory activity of the crude extract, alkaloid fraction, and solanine alkaloid. These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear edema and MPO activity of 100% and 65%, respectively. These results found probably are related to the presence of solanine which is present in significant quantity in the alkaloid fraction and others as rutin and rosmarinic, chlorogenic, and gallic acids. These results support the use of for the treatment of inflammatory skin disorders.
本研究的目的是评估粗提取物、生物碱部分和茄碱生物碱的抗炎活性。这些样品以剂量依赖性方式减轻巴豆油诱导的耳部水肿，在剂量分别为1.0、0.73和0.37mg/耳时，最大抑制率分别为81%、98%和80%。此外，这些样品抑制MPO活性，在剂量分别为1.0、0.73和0.37mg/耳时，最大抑制率分别为51%、40%和46%。对于0.10mg/耳的地塞米松（阳性对照）也发现了类似结果，其耳部水肿和MPO活性的抑制率分别为100%和65%。这些结果可能与生物碱部分中大量存在的茄碱以及芦丁、迷迭香酸、绿原酸和没食子酸等其他成分有关。这些结果支持将其用于治疗炎症性皮肤病。
