面向化学家的实用高通量实验方法
Practical High-Throughput Experimentation for Chemists.
作者信息
Shevlin Michael
机构信息
Department of Process Research & Development, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.
出版信息
ACS Med Chem Lett. 2017 May 17;8(6):601-607. doi: 10.1021/acsmedchemlett.7b00165. eCollection 2017 Jun 8.
Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.
大量由假设驱动、经过合理设计的实验是解决复杂化学问题的有力工具。本文讨论了化学高通量实验的概念和实际应用方面。文中举例说明了一个案例研究，即高通量实验在药物发现计划中的一个关键合成步骤中的应用，以及随后对一种候选药物首次大规模合成的优化。
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