Kim Hye Youn, Jang Kuk Jin, Veerapandian Murugan, Kim Hyung Chul, Seo Yeong Tai, Lee Kook Nyung, Lee Min-Ho
Korea Electronics Technology Institute, 68 Yatap-dong, Bundang-gu, Seongnam, Gyeonggi Do 463-816, South Korea.
Department of Chemistry, University of Montreal, 2900 Edouard Montpetit, Montreal, Quebec H3T 1J4, Canada.
Biotechnol Rep (Amst). 2014 Jun 20;3:49-53. doi: 10.1016/j.btre.2014.06.003. eCollection 2014 Sep.
An electrochemical based system with multiple layers coated on a functionalized graphene oxide Au electrode was developed to measure glucose concentration in urine in a more stable way. Two types of gold printed circuit boards were fabricated and graphene oxide was immobilized on their surface by chemical adsorption. Multiple layers, composed of a couple of polymers, were uniformly coated on the surface electrode. This device exhibited higher electrochemical responses against glucose, a greater resistivity in the presence of interferential substances in urine, and durable stabilities for longer periods of time than conventional units. The efficiency in current level according to the order and ratio of solution was evaluated during the immobilization of the layer. The fabricated electrodes were then also evaluated using hyperglycemic clinical samples and compared with the patterns of blood glucose measured with commercially available glucose meters. Our findings show that not only was their pattern similar but this similarity is well correlated.
开发了一种基于电化学的系统，该系统在功能化的氧化石墨烯金电极上涂覆了多层涂层，以更稳定的方式测量尿液中的葡萄糖浓度。制作了两种类型的印刷电路板，并通过化学吸附将氧化石墨烯固定在其表面。由几种聚合物组成的多层被均匀地涂覆在表面电极上。与传统装置相比，该装置对葡萄糖表现出更高的电化学响应，在尿液中存在干扰物质时具有更高的电阻率，并且在更长的时间内具有持久的稳定性。在固定层的过程中，根据溶液的顺序和比例评估了电流水平的效率。然后还使用高血糖临床样本对制作的电极进行了评估，并与使用市售血糖仪测量的血糖模式进行了比较。我们的研究结果表明，它们不仅模式相似，而且这种相似性具有良好的相关性。
