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B lymphocytes and cancer: a love-hate relationship.B淋巴细胞与癌症：爱恨交织的关系。
Trends Cancer. 2016 Dec;2(12):747-757. doi: 10.1016/j.trecan.2016.10.010.
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B cell conducts the lymphocyte orchestra.B细胞指挥着淋巴细胞“管弦乐队”。
J Autoimmun. 2007 Mar-May;28(2-3):143-51. doi: 10.1016/j.jaut.2007.02.011. Epub 2007 Mar 23.
3
Immunology. Take-charge B cells create a buzz.免疫学。主动型B细胞引发热议。
Science. 2009 Jul 10;325(5937):144-5. doi: 10.1126/science.325_144.
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The double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy.B细胞在介导抗肿瘤T细胞免疫中的双重作用：癌症免疫治疗的药理学策略。
Int Immunopharmacol. 2016 Jul;36:73-85. doi: 10.1016/j.intimp.2016.04.018. Epub 2016 Apr 22.
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CD20+ B cells: the other tumor-infiltrating lymphocytes.CD20+ B 细胞：另一种肿瘤浸润淋巴细胞。
J Immunol. 2010 Nov 1;185(9):4977-82. doi: 10.4049/jimmunol.1001323.
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Editorial overview: B cell shades of diversity and memory.社论综述：B细胞多样性与记忆的不同层面
Curr Opin Immunol. 2019 Apr;57:iii-vi. doi: 10.1016/j.coi.2019.04.006.
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Multiple routes to B-cell memory.B 细胞记忆的多种途径。
Int Immunol. 2012 Jul;24(7):403-8. doi: 10.1093/intimm/dxs050. Epub 2012 Mar 26.
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Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies.对恶性肿瘤患者的血液、淋巴结和肿瘤中的多克隆 B 细胞特征进行分析。
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Vaccination against encapsulated bacteria in humans: paradoxes.人类针对包膜细菌的疫苗接种：矛盾之处。
Trends Immunol. 2005 Feb;26(2):85-9. doi: 10.1016/j.it.2004.11.004.
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Understand memory, design better vaccines.理解记忆，设计更好的疫苗。
Nat Immunol. 2011 Jun;12(6):463-5. doi: 10.1038/ni.2041.

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The Value of the Naples Prognostic Score at Diagnosis as a Predictor of Cervical Cancer Progression.那不勒斯诊断预后评分作为宫颈癌进展预测指标的价值。
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Bioinformatics Screening of Tumor-Derived Neuropeptides Mediating Neuroimmune Axis of Head and Neck Cancer.介导头颈癌神经免疫轴的肿瘤衍生神经肽的生物信息学筛选
Cancers (Basel). 2025 Jul 25;17(15):2464. doi: 10.3390/cancers17152464.
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Expression of immunophenotypic markers in blood mononuclear cells of patients with advanced head and neck squamous cells carcinoma.晚期头颈部鳞状细胞癌患者血液单核细胞中免疫表型标志物的表达
Acta Cir Bras. 2025 Aug 8;40:e405425. doi: 10.1590/acb405425. eCollection 2025.
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Acute and subacute toxicity of the aqueous extract of Cissus Polyantha Glig and Bradt (Vitaceae) on biochemical and hematological parameters in Wistar rats.多花白粉藤（葡萄科）水提取物对Wistar大鼠生化和血液学参数的急性和亚急性毒性
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ImmuProgML: machine learning-based dissection of cancer-immune dynamics during tumor progression to improve immunotherapy.免疫进展机器学习（ImmuProgML）：基于机器学习剖析肿瘤进展过程中的癌症免疫动力学以改善免疫治疗。
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Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages.多胺代谢通过调节肿瘤相关巨噬细胞的免疫表型促进甲状腺癌进展。
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Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma.Derlin-3调控肺腺癌中内质网应激及浆细胞的IgG4分泌。
Oncogene. 2025 May 14. doi: 10.1038/s41388-025-03435-8.
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Molecular Biology and Functions of T Follicular Helper Cells in Cancer and Immunotherapy.癌症与免疫治疗中滤泡辅助性T细胞的分子生物学及功能
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本文引用的文献

1
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.通过单细胞RNA测序剖析转移性黑色素瘤的多细胞生态系统
Science. 2016 Apr 8;352(6282):189-96. doi: 10.1126/science.aad0501.
2
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.CD5与白细胞介素-6结合，并在B细胞中与转录因子STAT3形成前馈环以促进癌症。
Immunity. 2016 Apr 19;44(4):913-923. doi: 10.1016/j.immuni.2016.04.003.
3
SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.脊髓刺激巨噬细胞通过限制肿瘤衍生囊泡与B细胞的相互作用来抑制黑色素瘤。
Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.
4
The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.B细胞在自身免疫、感染和癌症中的调节作用：超越白细胞介素10产生的视角
FEBS Lett. 2015 Nov 14;589(22):3362-9. doi: 10.1016/j.febslet.2015.08.048. Epub 2015 Sep 28.
5
Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals.肿瘤微环境中的B细胞通过调节白细胞介素-8/雄激素受体（AR）/基质金属蛋白酶信号促进膀胱癌转移。
Oncotarget. 2015 Sep 22;6(28):26065-78. doi: 10.18632/oncotarget.4569.
6
From mice to humans: developments in cancer immunoediting.从小鼠到人类：癌症免疫编辑的进展
J Clin Invest. 2015 Sep;125(9):3338-46. doi: 10.1172/JCI80004. Epub 2015 Aug 4.
7
Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth.调节性B细胞优先聚集在肿瘤引流淋巴结中，并促进肿瘤生长。
Sci Rep. 2015 Jul 20;5:12255. doi: 10.1038/srep12255.
8
Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells.髓源性抑制细胞的免疫抑制和促转移功能依赖于肿瘤相关B细胞的“教育”。
Cancer Res. 2015 Sep 1;75(17):3456-65. doi: 10.1158/0008-5472.CAN-14-3077. Epub 2015 Jul 16.
9
Antibody-independent functions of B cells: a focus on cytokines.B 细胞的抗体非依赖性功能：聚焦细胞因子。
Nat Rev Immunol. 2015 Jul;15(7):441-51. doi: 10.1038/nri3857. Epub 2015 Jun 12.
10
Regulatory B cells in anti-tumor immunity.抗肿瘤免疫中的调节性B细胞。
Int Immunol. 2015 Oct;27(10):521-30. doi: 10.1093/intimm/dxv034. Epub 2015 May 20.

B lymphocytes and cancer: a love-hate relationship.

作者信息

Yuen Grace J, Demissie Ezana, Pillai Shiv

机构信息

Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge MA 02139.

出版信息

Trends Cancer. 2016 Dec;2(12):747-757. doi: 10.1016/j.trecan.2016.10.010.

DOI:10.1016/j.trecan.2016.10.010
PMID:28626801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5472356/
Abstract
摘要